Publications by authors named "M L Hansmann"
Article Synopsis
- - The lymph node is structured into dynamic compartments like T and B zones, which enhance both innate and adaptive immune responses and have led to new insights across various biological and medical fields.
- - The review emphasizes advanced 3D and 4D imaging techniques to study human lymph nodes, highlighting the insights gained from these methods compared to traditional 2D tissue analysis, particularly in understanding immune interactions and lymphoma behavior.
- - Findings show that T cells move faster than B cells and reticulum cells within reactive lymphoid tissue, with variations in cell contact times potentially aiding in lymphoma classification; 4D technology can also play a key role in testing new cancer therapies.
Salt metathesis of dinickel(II) complex LNiBr (1; L is a dinucleating pyrazolate ligand with two β-diketiminato chelate arms) with Na(OCP) ⋅ (dioxane) yielded LNi(PCO) (2) with a P-bridging phosphaethynolate. Further reaction of 2 with benzyl isocyanide or with an N-heterocyclic carbene (NHC) triggered decarbonylation and gave LNi(PCN-CHPh) (3) and LNiP(NHC) (4) with P-bridging cyanophosphide and NHC-phosphinidenide, respectively. Electronic structure analysis indicated a μ-η : η binding mode of the PCO anion between the two Ni ions in 2, which is even more pronounced for the [PCN(-CHPh)] anion in 3.
View Article and Find Full Text PDFPurpose: By considering work-related aspects during early intervention and treatment of employees with (subclinical) symptoms of common mental disorders, psychotherapeutic consultation at work (PT-W) aims to increase work-specific self-efficacy (SE) to finally reduce sickness absence and contribute to successful return to work. This study, thus, aims to investigate interrelations between working conditions and work-specific SE among employees before receiving PT-W.
Methods: The study uses baseline data of a randomized controlled trial testing the efficacy of PT-W in Germany (n = 535).
Article Synopsis
- Normal and malignant B cells have unique immunoglobulin (Ig) genes that can act as markers due to their high diversity.
- A laser-based microdissection method is used to isolate single B cells from frozen tissue sections and amplify specific rearranged Ig genes through semi-nested PCR.
- Analyzing these genes allows researchers to determine the clonal relationships of B cells, their gene usage, and their differentiation stage based on mutation patterns.
Article Synopsis
- - Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive B-cell lymphoma, and its subtypes have varying outcomes, prompting efforts to better predict patient prognosis based on cell origin.
- - This study focused on analyzing the migration abilities of two genetic subtypes of DLBCL, MCD and EZB, using specific tests to measure their movement through microchannels and narrow spaces.
- - Results showed that EZB-type cells migrated faster and more effectively through constrictions than MCD-type cells, which had higher levels of a protein affecting nuclear stiffness, suggesting that genetic differences may impact both therapy outcomes and tumor cell motility.