Publications by authors named "M L Guevara-Fujita"
Background: Tuberculosis (TB) is a highly prevalent chronic infectious disease in developing countries, with Peru being one of the most affected countries in the world. The variants of the -acetyltransferase 2 () gene are related to xenobiotic metabolism and have potential usefulness in TB studies.
Aim: To determine whether gene variants and acetylator phenotypes are associated with active TB in Peruvian patients.
Article Synopsis
- The study aimed to analyze how genetic variations in the VKORC1 and CYP2C9 genes affect warfarin maintenance doses in Peruvian patients on anticoagulation therapy.
- Conducted in a hospital in Lima, the research included 70 outpatients who had stable warfarin doses and appropriate blood clotting levels, with DNA samples collected for genetic analysis.
- Results showed that patients with the AA genotype of the VKORC1 gene needed a significantly lower average dose of warfarin compared to those with the GA and GG genotypes, while no notable association was found with the CYP2C9 gene.
Background: Promoter hypermethylation is one of the enabling mechanisms of hallmarks of cancer. Tumor suppressor genes like RARB and GSTP1 have been reported as hypermethylated in breast cancer tumors compared with normal tissues in several populations. This case-control study aimed to determine the association between the promoter methylation ratio (PMR) of RARB and GSTP1 genes (separately and as a group) with breast cancer and its clinical-pathological variables in Peruvian patients, using a liquid biopsy approach.
View Article and Find Full Text PDFBackground: Epidermolysis bullosa (EB) is a complex and heterogeneous dermatological disease. Four main types of EB have been described, each of them with distinct characteristics: EB simplex (EBS), dystrophic EB (DEB), junctional EB (JEB) and Kindler EB (KEB). Each main type varies in its manifestations, severity, and genetic abnormality.
View Article and Find Full Text PDFBackground: We report the molecular analysis of the DMD gene in a group of Peruvian patients with Duchenne/Becker dystrophinopathy. This is the first study to thoroughly characterize mutations in this population.
Methods: We used the combination of multiplex ligation-dependent probe amplification (MLPA) and sequencing analysis of the DMD gene.