Publications by authors named "M L G Tejada"
Diagnostic performance of ChatGPT-4.0 in histopathological description analysis of oral and maxillofacial lesions: a comparative study with pathologists.
Oral Surg Oral Med Oral Pathol Oral Radiol
November 2024
Article Synopsis
- The study evaluated ChatGPT-4.0's ability to diagnose oral and maxillofacial lesions by analyzing 102 histopathological cases and comparing its performance to that of pathologists.
- ChatGPT-4.0 achieved an accuracy of about 59.8%, diagnosing 61 cases correctly, with varying success depending on lesion type—being particularly poor with granulomas and inflammation, but strong with mucoceles.
- There was a notable correlation between age and accuracy, indicating that older ages might be associated with lower diagnostic scores, although gender did not significantly affect results.
A circular economy process has been developed to convert polyurethane waste into biofertilizing microorganisms through a sequential chemical/biological process. The chemical phase involves the complete depolymerization of polyurethane using ozone attack, generating an aqueous extract (OLE) composed of small, bioavailable molecules such as polyols, isocyanate derivatives, and carboxylic acids. The biological phase utilizes OLE for the generation of biomass with biofertilizing functional activity through Rhodococcus pyridinivorans fermentation.
View Article and Find Full Text PDFThe peripheral inflammatory response is an attractive therapeutic target for pain treatment. Neutrophils are the first circulating inflammatory cells recruited to sites of injury, but their contribution to pain outcomes is unclear. We performed a systematic review and meta-analysis of original preclinical studies, which evaluated the effect of preemptive neutrophil depletion on pain outcomes (PROSPERO registration number: CRD42022364004).
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- P2X3 and P2X2/3 receptor inhibitors are being targeted for pain relief, and this study reviews preclinical data on their effectiveness.
- A meta-analysis of 67 articles revealed a significant overall pain reduction, particularly effective for visceral pain and mechanical hypersensitivity, with no notable differences based on sex or species.
- The route of administration mattered: systemic methods were more effective than intrathecal, while intracerebroventricular methods worsened pain; overall, further clinical research is needed to translate these findings into treatments.
Postoperative pain management is challenging. We used mice with a transverse laparotomy to study tactile allodynia measured by the von Frey test, pain at rest measured by facial pain expressions detected by an artificial intelligence algorithm, and movement-induced pain measured by reductions in exploratory activity. The standard analgesics morphine and ibuprofen induced distinct patterns of outcome-dependent effects.
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