Randomized clinical trial of imiquimod compared with fludroxycortide in the treatment of actinic cheilitis.

Objective: actinic cheilitis (AC) is a potentially malignant disorder of the lip vermillion. The study of effective therapeutic options is of the utmost importance to prevent the development of lip squamous cell carcinoma. This study aimed to evaluate the topical effect of imiquimod 5% (IM) and fludroxycortide (FC) 0.

Characterisation of GPR17-expressing oligodendrocyte precursors in human ischaemic lesions and correlation with reactive glial responses.

White matter damage and subsequent demyelination significantly contribute to long-term functional impairment after ischaemic stroke. Identifying novel pharmacological targets to restore myelin integrity by promoting the maturation of oligodendrocyte precursor cells (OPCs) into new myelinating oligodendrocytes may open new perspectives for ischaemic stroke treatment. In this respect, previous studies highlighted the role of the G protein-coupled membrane receptor 17 (GPR17) as a key regulator of OPC differentiation in experimental models of brain injury, including ischaemic stroke.

Effects of red blood cell transfusion on cerebral hemodynamics of preterm neonates.

Significance: Anemia is a common problem in preterm neonates, and red blood cell transfusion (RBCT) is used to improve oxygen delivery. However, RBCT is associated with complications, although an increase in cerebral oxygenation has been documented, and no universally accepted biomarker for the need for transfusion (i.e.

Design and Validation of an Obstacle Contact Sensor for Aerial Robots.

Obstacle contact detection is not commonly employed in autonomous robots, which mainly depend on avoidance algorithms, limiting their effectiveness in cluttered environments. Current contact-detection techniques suffer from blind spots or discretized detection points, and rigid platforms further limit performance by merely detecting the presence of a collision without providing detailed feedback. To address these challenges, we propose an innovative contact sensor design that improves autonomous navigation through physical contact detection.