Arch Gynecol Obstet
November 2024
Background: The role of factor XIII in acute bleeding situations is gaining more and more importance. It has previously been shown that prepartum factor XIII activity has a significant impact on postpartum blood loss. Whether factor XIII antigen behaves in a similar manner is unknown.
View Article and Find Full Text PDFGeburtshilfe Frauenheilkd
September 2024
Background: Fifteen to thirty percent of all patients with metastatic breast cancer (MBC) develop brain metastases (BCBMs). Recently, the antibody-drug conjugates (ADCs) sacituzumab govitecan (SG) and trastuzumab deruxtecan (T-DXd) have shown to be highly effective in the treatment of MBC. However, there are only limited data whether these macromolecules are also effective in patients with BCBMs.
View Article and Find Full Text PDFBackground: Following the positive iDFS and OS results of the phase III clinical trials monarchE, NATALEE and OlympiA, new oral anticancer agents (the CDK4/6 inhibitors abemaciclib, ribociclib as well as the PARP inhibitor olaparib) have recently been introduced into the treatment of high-risk early breast cancer (eBC). However, only few male patients were included in these trials (0.4%, 0.
View Article and Find Full Text PDFBackground: The aim of the present study was to describe an unselected population of patients with diagnosis of FIGO stage IV OC.
Methods: Data from 1183 patients were available for analysis.
Results: The majority of patients (962/1183, 81.