Publications by authors named "M L France"
Article Synopsis
- The vaginal microbiota plays a significant role in the health of women and newborns, but its ecological dynamics and stability are not fully understood.
- This study investigates how nutritional resources, particularly glycogen and sialic acid, influence the composition of vaginal bacterial communities, highlighting the connection between resource availability and bacterial behavior.
- Using a new mathematical model, the research finds that bacteria associated with bacterial vaginosis (BV) thrive due to their exclusive access to certain nutrients, which helps them resist changes in their community structure, providing insights for potential BV prevention strategies.
are major contributors of sialidases in the human vaginal microbiome.
Proc Natl Acad Sci U S A
September 2024
Elevated bacterial sialidase activity in the female genital tract is strongly associated with poor health outcomes including preterm birth and bacterial vaginosis (BV). These negative effects may arise from sialidase-mediated degradation of the protective mucus layer in the cervicovaginal environment. Prior biochemical studies of vaginal bacterial sialidases have focused solely on the BV-associated organism .
View Article and Find Full Text PDFArticle Synopsis
- Atherosclerotic cardiovascular disease (ASCVD) risk has traditionally focused on lowering LDL cholesterol, but this review highlights the significance of hypertriglyceridaemia as another critical risk factor.
- Despite treating patients with LDL-lowering therapies, high triglyceride levels continue to pose a risk for ASCVD, especially when paired with low HDL cholesterol levels.
- Recent studies show mixed results regarding triglyceride-lowering medications, with purified eicosapentaenoic acid (EPA) showing promise, suggesting the need for updated clinical guidelines and further investigation into novel therapies targeting other ASCVD risk factors.
Objective: Menopause is often accompanied by lowered Lactobacillus spp. relative abundance and increased abundance of diverse anaerobic/aerobic bacteria in the vaginal microbiota due in part to declines in estrogen. These microbiota are associated with urogenital symptoms and infections.
View Article and Find Full Text PDFArticle Synopsis
- Colonization by harmful bacteria like Gardnerella vaginalis and Mobiluncus mulieris increases the risk of STIs and reproductive issues, while Lactobacillus crispatus supports healthy reproductive functions.
- Bacterial extracellular vesicles (bEVs) are thought to play a key role in how these bacteria communicate with host cells and may influence immune responses.
- Research shows that bEVs from harmful bacteria can trigger an inflammatory response in cervical and vaginal cells, highlighting the potential link between these bacteria and negative reproductive health outcomes.