Differential disruption of response alternation by precipitated Δ-THC withdrawal and subsequent Δ-THC abstinence in mice.

In addition to overt somatic symptoms, cannabinoid withdrawal can also manifest as disruptions in motivation and attention. Experimental animal models using operant-conditioning approaches reveal these differences, in either antagonist-precipitated or spontaneous withdrawal models. However, these processes have yet to be characterized in the same subjects simultaneously.

A behavioral timing intervention upregulates striatal serotonergic markers and reduces impulsive action in adult male mice.

Many studies support the hypothesis that time-based interventions reduce impulsive behavior in rodents. However, few studies have directly assessed 1) how such interventions affect impulsive action rather than impulsive choice, 2) if intervention effects differ by sex, and 3) how time-based interventions affect neurochemistry in regions mediating decision-making and reward. Thus, we assessed how a fixed-interval (FI) intervention initiated during late adolescence and extending into adulthood affected dopaminergic and serotonergic analytes in the frontal cortex and striatum and subsequent impulsive action in adult male and female mice.

Neonatal exposure to ultrafine iron but not combined iron and sulfur aerosols recapitulates air pollution-induced impulsivity in mice.

Air pollution (AP) is becoming recognized as a major threat to neurological health across the lifespan with increased risk of both neurodevelopmental and neurodegenerative disorders. AP is a complex mixture of gases and particulate matter, with adsorbed contaminants including metals and trace elements, which may differentially contribute to its neurodevelopmental impacts. Iron (Fe) is one of the most abundant metals found in AP, and Fe concentrations may drive some behavioral deficits observed in children.

The potential involvement of inhaled iron (Fe) in the neurotoxic effects of ultrafine particulate matter air pollution exposure on brain development in mice.

Background: Air pollution has been associated with neurodevelopmental disorders in epidemiological studies. In our studies in mice, developmental exposures to ambient ultrafine particulate (UFP) matter either postnatally or gestationally results in neurotoxic consequences that include brain metal dyshomeostasis, including significant increases in brain Fe. Since Fe is redox active and neurotoxic to brain in excess, this study examined the extent to which postnatal Fe inhalation exposure, might contribute to the observed neurotoxicity of UFPs.

The impact of the shift to cloud computing on digital recordkeeping practices at the University of Michigan Bentley historical library.

Cloud-based productivity, collaboration, and storage tools offer increased opportunities for collaboration and potential cost-savings over locally hosted solutions and have seen widespread adoption throughout industry, government, and academia over the last decade. While these tools benefit organizations, IT departments, and day-to-day-users, they present unique challenges for records managers and archivists. As a review of the relevant literature demonstrates, issues surrounding cloud computing are not limited to the technology-although the implementation and technological issues are numerous-but also include organization management, human behavior, regulation, and records management, making the process of archiving digital information in this day and age all the more difficult.