Publications by authors named "M L Durham"
Background: Haptics-enhanced virtual reality (VR-haptic) simulation in dental education has evolved considerably during the past decade, representing a promising resource of simulation-based training opportunities to support conventional practice. We aim to summarize current literature on the applications of VR-haptics in learning, practicing, and teaching dental education.
Methods: A literature search was performed using PubMed, focusing on research articles published between January 2010 and January 2024.
Mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene cause Rett syndrome, a severe childhood neurological disorder. MeCP2 is a well-established transcriptional repressor, yet upon its loss, hundreds of genes are dysregulated in both directions. To understand what drives such dysregulation, we deleted Mecp2 in adult mice, circumventing developmental contributions and secondary pathogenesis.
View Article and Find Full Text PDFBackground: Hirschsprung associated enterocolitis (HAEC) is a challenging problem in a subset of children with Hirschsprung disease (HD). In refractory cases, fecal diversion may be required. The aim of this study was to characterize patients who require fecal diversion for HAEC management and examine their long-term outcomes.
View Article and Find Full Text PDFArticle Synopsis
- SLITs are proteins that act as ligands for ROBO receptors, which are important for cell signaling.
- Research indicates that ROBO1 helps mammary cells differentiate and produce milk by blocking Notch signaling.
- In experiments, knockout mice lacking SLIT2 and SLIT3 showed better development of milk-producing cells and higher milk production, suggesting that SLITs inhibit this process by interfering with ROBO1.
Article Synopsis
- This study is about helping doctors and surgeons find the best ways to diagnose and treat skin cancers in kids and teenagers, especially types like cutaneous melanoma and atypical Spitz tumors.
- A group of 33 skin cancer specialists from different fields worked together and used research to come up with their recommendations.
- They suggested specific ways to perform surgeries, the importance of classifying tumors correctly, and rules about how much tissue to remove around suspicious areas.