Publications by authors named "M L Dourson"
Many government agencies and expert groups have estimated a dose-rate of perfluorooctanoate (PFOA) that would protect human health. Most of these evaluations are based on the same studies (whether of humans, laboratory animals, or both), and all note various uncertainties in our existing knowledge. Nonetheless, the values of these various, estimated, safe-doses vary widely, with some being more than 100,000 fold different.
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- - Noncancer risk assessment methods have evolved significantly since the 1980s, moving beyond simple calculations to more sophisticated approaches, influenced by key organizations and workshops aimed at improving risk assessment practices.
- - Several case studies have shown that the assessment of non-cancer toxicity and the integration of cancer and non-cancer evaluation methods involves complex considerations, rather than just applying uniform thresholds.
- - The National Academy of Sciences (NAS) recommends engaging risk managers early in the risk assessment process to focus on practical solutions like establishing a safe dose, suggesting that not all environmental issues require exact numerical answers.
The Conundrum of the PFOA human half-life, an international collaboration.
Regul Toxicol Pharmacol
July 2022
The Steering Committee of the Alliance for Risk Assessment (ARA) opened a call for scientists interested in resolving what appeared to be a conundrum in estimating of the half-life of perfluorooctanoate (PFOA) in humans. An Advisory Committee was formed from nominations received and a subsequent invitation led to the development of three small independent working groups to review appropriate information and attempt a resolution. Initial findings were shared among these groups and a conclusion developed from the ensuing discussions.
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