Publications by authors named "M L Dominguez Grande"
Optical approaches to monitor neural activity are transforming neuroscience, owing to a fast-evolving palette of genetically encoded molecular reporters. However, the field still requires robust and label-free technologies to monitor the multifaceted biomolecular changes accompanying brain development, aging or disease. Here, we have developed vibrational fiber photometry as a low-invasive method for label-free monitoring of the biomolecular content of arbitrarily deep regions of the mouse brain in vivo through spontaneous Raman spectroscopy.
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- - Laser-based mid-IR photothermal spectroscopy (PTS) is a rapid and sensitive analytical method that utilizes advanced laser technology to capture the absorption characteristics of various materials, such as liquids or solids.
- - This study utilizes an external cavity quantum cascade laser (EC-QCL) to analyze a thin film of polymethyl methacrylate (PMMA) on a silicon nitride micro-ring resonator, demonstrating its effectiveness in creating an on-chip photothermal sensor.
- - The research highlights the optimal alignment and focusing techniques for the laser setup, showing that PTS can lead to compact, efficient sensors suitable for real-time monitoring in industrial applications.
We propose a strategy to monolithically integrate active III-V lasers and passive dielectric devices, where the passive waveguides are fabricated after the MBE growth of the III-V semiconductors on a planar Si substrate. This avoids any airgap at the active/passive interface, replaced by a thin dielectric interface layer which improves the light coupling efficiency. We demonstrate GaSb DLs butt-coupled to SiN waveguides with ∼23% transmission after 2 mm SiN, corresponding to ∼35% transmission at the active/passive interface.
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- The study addresses the issue of low attendance at cardiac rehabilitation (CR) by analyzing data from 33,055 patients in Queensland over two years to identify characteristics affecting CR participation.
- Results reveal that 37% of patients declined CR, 35% started but didn't finish, and 28% completed it, with age, Indigenous status, living location, and specific heart conditions being key factors linked to non-attendance and non-completion.
- The findings suggest that targeted initiatives are needed to improve CR participation, particularly for Indigenous populations and those with certain demographic and health-related characteristics.
Neuroinflammation has recently emerged as a crucial factor in Alzheimer's disease (AD) etiopathogenesis. Microglial cells play an important function in the inflammatory response; specifically, the emergence of disease-associated microglia (DAM) has offered new insights into the conflicting perspectives on the detrimental or beneficial roles of microglia. We previously showed that modulating the endocannabinoid tone by fatty acid amide hydrolase (FAAH) inactivation renders beneficial effects in an amyloidosis context, paradoxically accompanied by an exacerbated neuroinflammatory response and the enrichment of DAM population.
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