Publications by authors named "M L Dewar"

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Highly pathogenic avian influenza (HPAI) viruses are increasingly spreading between birds and mammals globally, with sporadic transmission to humans. With recent emergence in Antarctica, traditional animal capture and influenza testing approaches have proven challenging and logistically impractical. Without reference laboratories in the region, responses are slow and few samples will ever be collected or tested from local outbreaks due to lack of infrastructure.

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Article Synopsis
  • The study investigates how the right ventricle (RV) of the heart remodels in response to increased pressure over a span of six weeks, focusing on the early changes that could inform treatment timing.
  • Researchers found that within the first week after introducing pressure (using pulmonary artery banding), there was a significant inflammatory response and changes in cellular metabolism that suggested RV stress.
  • The findings imply that detrimental changes in RV function start earlier than previously thought, indicating that interventions to prevent RV remodeling may need to happen sooner than current practices suggest.
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The current highly pathogenic avian influenza H5N1 panzootic is having substantial impacts on wild birds and marine mammals. Following major and widespread outbreaks in South America, an incursion to Antarctica occurred late in the austral summer of 2023/2024 and was confined to the region of the Antarctic Peninsula. To infer potential underlying processes, we compiled H5N1 surveillance data from Antarctica and sub-Antarctic Islands prior to the first confirmed cases.

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