Unlocking genetic diversity for low-input systems in a changing climate through participatory characterization and GWAS of lentil landraces.

Lentils are a vital staple crop in a world seeking sustainable and secure food, but their cultivation face a threat due to yield instability, mainly arising from a lack of genetic diversity in breeding programmes. In this study, we assembled and characterized the genetic and phenotypic diversities of a collection of 106 lentil genotypes, to evaluate their breeding and cropping potential. Lentil landraces from Italy and beyond, either abandoned or still cultivated, were collected from genebanks, seed savers, universities and farmers.

Transcriptome profiling of eight Zea mays lines identifies genes responsible for the resistance to Fusarium verticillioides.

Background: The cultivation of maize (Zea mays L.), one of the most important crops worldwide for food, feed, biofuels, and industrial applications, faces significant constraints due to Fusarium verticillioides, a fungus responsible for severe diseases including seedling blights, stalk rot, and ear rot. Its impact is worsened by the fact that chemical and agronomic measures used to control the infection are often inefficient.

Synapse-to-nucleus ERK-CREB transcriptional signaling requires dendrite-to-soma Capropagation mediated by L-type voltage-gated Ca channels.

The cAMP-response element binding protein (CREB) transcription factor controls the expression of the neuronal immediate early genes , , and and is essential for long-lasting synaptic plasticity underlying learning and memory. Despite this critical role, there is still ongoing debate regarding the synaptic excitation-transcription (E-T) coupling mechanisms mediating CREB activation in the nucleus. Here we employed optical uncaging of glutamate to mimic synaptic excitation of distal dendrites in conjunction with simultaneous imaging of intracellular Ca dynamics and transcriptional reporter gene expression to elucidate CREB E-T coupling mechanisms in hippocampal neurons cultured from both male and female rats.

Endovascular therapy in patients with acute intracranial non-terminal internal carotid artery occlusion (ICA-I).

Background: Acute intracranial occlusion of the internal carotid artery (ICA) can be distinguished into (a) occlusion of the terminal ICA, involving the proximal segments of the middle or anterior cerebral artery (ICA-L/-T) and (b) non-terminal intracranial occlusions of the ICA with patent circle of Willis (ICA-I). While patients with ICA-L/-T occlusion were included in all randomized controlled trials on endovascular therapy (EVT) in anterior large vessel occlusion, data on EVT in ICA-I occlusion is scarce. We thus aimed to evaluate effectiveness and safety of EVT in ICA-I occlusions in comparison to ICA-L/-T occlusions.