Publications by authors named "M L De Buyzere"

Article Synopsis
  • The study investigates how renal artery stenosis (RAS) affects blood flow and renin release in a pig model, particularly when there is significant stenosis on the opposite kidney side.
  • Researchers measured kidney pressure and blood flow while gradually blocking the renal artery to understand how these changes impact renin secretion.
  • Findings revealed that a 25% reduction in renal perfusion pressure significantly reduced blood flow and increased renin release, especially when there was already significant stenosis in the contralateral kidney.
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The molecular mechanisms contributing to large artery stiffness (LAS) are not fully understood. The aim of this study was to investigate the association between circulating plasma proteins and LAS using complementary proteomic and genomic analyses. A total of 106 proteins associated with carotid-femoral pulse-wave velocity, a noninvasive measure of LAS, were identified in 1,178 individuals from the Asklepios study cohort.

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Objectives: Fecal immunochemical tests (FIT) for hemoglobin are currently considered the screening investigation of choice for colorectal cancer and are worldwide recommended. Similarly, fecal calprotectin is a widely used test for monitoring intestinal inflammation. The pre-analytical issues regarding stool samples have hardly been dealt with and are difficult to solve.

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Randomized clinical trials failed to show additional benefit of renal artery stenting on top of medical therapy. Instead of writing an obituary on renal artery stenting, we try to explain these disappointing results. A transstenotic pressure gradient is needed to reduce renal perfusion and to activate the renin-angiotensin-aldosterone system.

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