Antiaging Effects of Topical Defensins.

Topical defensins have recently gained attention as agents to improve skin composition. This study aimed to aggregate and synthesize studies in the literature assessing the effects of topical defensins on skin composition in the context of its ability to combat signs of aging.

[Electrophysiological and morphohistochemical study of adrenalectomy on the hippocampal neurons].

Chronic insufficiency of adrenal hormones is a pathology leading to brain dysfunction. In electrophysiological studies, by extracellular recording of spike activity of single hippocampal neurons (HN) caused by high-frequency stimulation of the entorhinal cortex (EC) in rats with unilateral removal of adrenal (adrenalectomy - AE), we analyzed mechanisms of adaptation of neural networks to chronic hormonal deprivation. The balance of excitatory and inhibitory responses, recorded in HN of intact rats was submitted to characteristic changes in dynamics of development of neurodegeneration: the dominating in norm inhibitory responses were decreased at all AE terms (from 42 % to 25 % by the 18th week).

[Reaction of the rat brain capillaries to immobilization stress].

Using calcium-adenosine triphosphate histoangiological method of Chilingarian, the morpho-functional state of the capillary limb of the microcirculatory bed in rat brain was studied at various time intervals after the exposure to experimental immobilization stress (fixation of the animals on the back for 2 hours). The analysis of morphometric data has show that in comparison with intact animals, immediately after the stress the capillaries were contracted by 17.2%, while on the second day their compensatory dilatation by 2.