Shape and Size Dependent Antimicrobial and Anti-biofilm Properties of Functionalized MoS.

Bacterial resistance, accelerated by the misuse of antibiotics, remains a critical concern for public health, promoting an ongoing exploration for cost-effective and safe antibacterial agents. Recently, there has been significant focus on various nanomaterials for the development of alternative antibiotics. Among these, molybdenum disulfide (MoS) has gained attention due to its unique chemical, physical, and electronic properties, as well as its semiconducting nature, biocompatibility, and colloidal stability, positioning it as a promising candidate for biomedical research.

Development of Nanomaterials-Based Agents for Selective Antibacterial Activity.

Bacterial infections continue to threaten public health due to limitations in rapid and accurate diagnostic techniques. While broad-spectrum antibiotics offer empirical treatment, their overuse has fuelled the emergence of antimicrobial resistance (AMR) pathogens, posing a critical global public health challenge. In this critical scenario, nanomaterial-based antibacterial agents emerge as a promising solution to combat bacteria and inhibit their proliferation.

Evidence for a sex-dependent effect modification in the association between IFN-λ DNA polymorphisms and expression of IFN-λ and interferon-stimulated genes in human PBMCs.

Human interferon (IFN) lambda (IFNL, IFN-L or IFN-λ) locus has several functional genetic variants but their role in regulating in vivo gene expression, and whether they associate with antiviral states in healthy individuals, is not clear. In this study, we recruited ∼550 healthy individuals belonging to both sexes, genotyped them for several IFNL genetic variants and measured, by qPCR, the expression of IFNL2/3, IFNL4 and four IFN-stimulated genes (ISGs) (MX1, OAS1, ISG15 and RSAD2) from their peripheral blood mononuclear cells (PBMC) both before and after stimulation with a viral mimic, poly I: C. We also measured secreted levels of several cytokines including IFN-λ1 and IFN-λ3 in poly I:C stimulated PBMCs.

Multistep Array-Based Sensing of Bioanalytes Using Modified MoS, Fluorescence Proteins, and Cucurbituril.

One pot sensor by multiplexing in the array is an attractive system for rapid discrimination of multiple analytes. Multiplexing can be achieved in two ways, i.e.

Host-Guest Interactions Induced Enhancement in Oxidase-Like Activity of a Benzothiadiazole Dye Inside an Aqueous PdL Barrel.

The effect of host-guest interactions on the chemistry of encapsulated molecules is a fascinating field of research that has gained momentum in recent years. Much of the work in this field has been focused on the effect of such interactions on catalysis and photoluminescence of encapsulated dyes. However, the effect of such interactions on related photoinduced processes, such as photoregulated oxidase-mimicking activity, has not been explored much.