Idiopathic CD4+ T-cell lymphocytopenia with verrucae, basal cell carcinomas, and chronic tinea corporis infection.

Idiopathic CD4+ T lymphocytopenia should be considered in HIV-negative patients with skin lesions commonly associated with HIV infection. Patients with idiopathic CD4+ T lymphocytopenia are presumably rare, often have dermatologic lesions, always have low CD4+ T lymphocyte counts, and lack all evidence of HIV-1 infection. We describe a young man with verrucae, basal cell carcinomas, chronic tinea corporis, and laboratory evidence supporting a diagnosis of idiopathic CD4+ T lymphocytopenia.

Neonatal lupus in twins.

Neonatal lupus erythematosus (NLE) is a syndrome characterized by one or all of the following elements: cutaneous LE lesions, systemic disease, and congenital heart block. SS-A/Ro and SS-B/La have been implicated in the etiology of NLE, but because NLE is not uniformly manifested in all offspring of SS-A and SS-B autoantibody positive mothers, and because of the wide range of clinical manifestations associated with NLE, other contributing etiologic factors are being explored. HLA studies have revealed that infants of SS-A/Ro and SS-B/La positive mothers bearing HLA-A1, B8, DR3, DQ2, and DR52 are at greater risk of having NLE.

Preliminary study of a Mycobacterium leprae bacterin vaccine in a human volunteer population in a nonendemic area.

Seventeen volunteers who had never resided in areas with significant transmission of leprosy (Hansen's disease) were inoculated intradermally with 1.5 X 10(8) killed, purified armadillo-derived Mycobacterium leprae in a standardized preparation being tested for possible vaccine use. The peak of local skin responses, consisting of induration with or without ulceration similar to the post-lepromin Mitsuda reaction, occurred between the 21st and 28th days after injection.