Ribosome specialization by cancer-associated ribosomal protein mutations: progress made and open questions.

Congenital mutations in ribosomal proteins (RPs) cause Diamond-Blackfan anaemia (DBA) syndrome. Whereas DBA patients suffer from anaemia and disease symptoms owing to a lack of cell proliferation (hypo-proliferation) early in life, they have a significantly elevated risk of developing cancer (a disease of hyper-proliferation) at a later age. The association between ribosome defects and cancer is further underscored by animal models in which heterozygous RP loss promotes tumourigenesis, as well as by a variety of somatic RP mutations that have been described in haematological and solid malignancies.

improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice.

Background: Alzheimer's disease (AD) is a growing public health problem in the aging population, with limited treatment options. We previously reported that herb water extract (CAW) attenuates cognitive decline in murine models of AD and aging.

Objective: To explore changes in the hippocampal metabolome associated with CAW's modulation of cognitive function and amyloid-β (Aβ) plaque load in aged Tg2576 and wild-type (WT) mice.

Automated Multicohort Mobility Assessment with an Instrumented L-test (iL-test).

The L-test is a performance-based measure to assess balance and mobility. Currently, the primary outcome from this test is the time required to finish it. In this study we present the instrumented L-test (iL-test), an L-test wherein mobility is evaluated by means of a wearable inertial sensor worn at the lower back.

Prevalence and Antimicrobial Resistance of Strains Isolated from Chicken Samples in Southern Italy.

Salmonellosis is one of the most frequent foodborne zoonoses, and the consumption of contaminated poultry meat is considered the main source of infections in humans. From 2021 to 2023, 384 chicken samples were collected from retailers in Apulia and Basilicata regions and analysed at the Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata (IZSPB) laboratories. The isolates were investigated to evaluate their phenotypic characteristics of antimicrobial resistance.

BRM: From Skin-Reducing Mastectomy to the New Concept of Breast Reshaping Mastectomy.

Macromastia is a well-known issue in breast reconstruction. Skin-reducing mastectomy (SRM) was introduced as a skin-sparing mastectomy that utilizes a skin reduction pattern similar to breast reduction or breast lift surgery, specifically to manage hypertrophic and pendulous breasts. Over time, numerous authors have contributed to refining the SRM technique, leading to the development of various technical variants.