Antimicrobial and genotoxic activities of N-hydroxyalkyl-1, 2-benzisothiazol-3(2H)-one carbamic esters.

N-Hydroxyethyl- and N-hydroxypropyl-1,2-benzisothiazol-3(2H)-one carbamic esters were prepared in order to test their activity against representative bacterial and fungal strains. The obtained results were compared with those reported for parent alcohols and some interesting considerations were drawn. None of the studied derivatives possess genotoxic activity in the Bacillus subtilis rec-assay and Salmonella-microsome test.

Fungicidal activity of arylfurylketoximes.

A series of arylfurylketoximes and their O-ethyl ethers and O-esters were prepared and evaluated for their fungicidal phytoiatric activity, in vitro and in vivo. The biological results show that the O-acetyderivatives and the free oximes present a very good activity.

Fungicidal activity of O-esters of benzophenone oximes.

Some acyl- and aroyl derivatives of benzophenone oximes variously benzene substituted were prepared and tested in vitro and in vivo against fungal plant pathogens of different taxonomic classes. The tested compounds showed remarkable activity, especially some O-acetyl derivatives.

Antimicrobial and genotoxic properties of quinoline derivatives.

We continued our research into the biological properties of quinoline derivatives. Newly synthesized 8-sulfonylquinolines, tested against some representative microbial strains and practically inactive, were also studied for the genotoxic properties. The genotoxicity tests were extended to previously synthesized compounds (some 6-substituted 8-quinolinecarboxylic acids, the amide and some esters of 8-quinolinecarboxylic acid and finally the 8-quinolinecarboxaldehyde and two of its derivatives).

Fungicidal and genotoxic activity of new substituted pyridazinones.

Some 2-sulfonyl- and 2-acylderivatives of the 4,5-dichloro-3(2H)-pyridazinone were prepared in order to test their fungicidal activity. Interesting results, both in vitro and in vivo, were obtained in particular from the alkylsulfonyl-derivatives. Genotoxic activity of 3(2H)-pyridazinones was evaluated in vitro by the Bacillus subtilis rec-assay and the Salmonella-microsome reversion assay.