Publications by authors named "M L Boyce"
Celiac disease is a chronic, immune-mediated enteropathy with symptoms triggered by exposure to dietary gluten in genetically predisposed individuals. The only available management option is lifelong adherence to a gluten-free diet. This randomized, double-blind, placebo-controlled, parallel-group, single-center study tested the effects of the cathepsin S inhibitor RO5459072 on the immune response to a 13-day gluten challenge in 19 participants with celiac disease (ClinicalTrials.
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- Caring for newborns limits mammalian females' ability to gather resources, especially during the energy-demanding early lactation period.
- Different ungulates have developed various strategies for protecting their vulnerable newborns, from staying hidden to being mobile, which can influence their mothers' movement patterns.
- A study of 54 populations of 23 ungulate species shows that maternal movements are affected by the resource availability and type of neonatal strategy, highlighting the importance of these tactics in understanding how species adapt to environmental changes.
Short circuit: Transcription factor addiction as a growing vulnerability in cancer.
Curr Opin Struct Biol
December 2024
Core regulatory circuitry refers to the network of lineage-specific transcription factors regulating expression of both their own coding genes, and that of other transcription factors. Such autoregulatory feedback loops coordinate the transcriptome and epigenome during development and cell fate decisions. This circuitry is hijacked during oncogenesis resulting in cancer cell fate being maintained by lineage-specific transcription factors.
View Article and Find Full Text PDFGlycosylation is biochemically complex and functionally critical to a wide range of processes and disease states, making it a vibrant area of contemporary research. Here, we highlight a selection of notable recent advances in the glycobiology of SARS-CoV-2 infection and immunity, cancer biology and immunotherapy, and newly discovered glycosylated RNAs. Together, these studies illustrate the significance of glycosylation in normal biology and the great promise of manipulating glycosylation for therapeutic benefit in disease.
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- The COVID-19 pandemic significantly affected emergency medicine resident physicians, impacting their training and psychological well-being as they navigate early stages of their careers.
- A qualitative study involved in-depth interviews with 27 personnel, including resident physicians, identifying three key themes: the challenges of novel educational experiences, disrupted social interactions, and the development of negative emotions and psychological trauma.
- Findings indicate that while some educational and social aspects had both positive and negative effects, the overall emotional experiences for residents were predominantly negative, highlighting the need for improved support systems.