Publications by authors named "M L Blundell"
Antenatal administration of extracellular vesicles from amniotic fluid stem cells (AFSC-EVs) reverses features of pulmonary hypoplasia in models of congenital diaphragmatic hernia (CDH). However, it remains unknown which lung cellular compartments and biological pathways are affected by AFSC-EV therapy. Herein, we conducted single-nucleus RNA sequencing (snRNA-seq) on rat fetal CDH lungs treated with vehicle or AFSC-EVs.
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- The Royal College of Emergency Medicine's Toxicology Special Interest Group partnered with the UK National Poisons Information Service and Guy’s and St Thomas’ NHS Foundation Trust to create guidance for emergency department clinicians on handling acute opioid toxicity in adults.
- The guidance includes advice on identifying cases of acute opioid toxicity and offers recommendations for treatment options and secondary prevention strategies.
- Emphasis is placed on utilizing the best available evidence to inform these recommendations and improve patient care.
Background: Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare and aggressive cancer predisposition syndrome. Because a scarcity of data on this condition contributes to management challenges and poor outcomes, we aimed to describe the clinical spectrum, cancer biology, and impact of genetics on patient survival in CMMRD.
Methods: In this cohort study, we collected cross-sectional and longitudinal data on all patients with CMMRD, with no age limits, registered with the International Replication Repair Deficiency Consortium (IRRDC) across more than 50 countries.
Article Synopsis
- This study investigates the effects of amniotic fluid stem cell-derived extracellular vesicles (AFSC-EVs) on lung development in fetal rats with congenital diaphragmatic hernia (CDH), a condition affecting respiratory function in newborns.
- Researchers induced CDH in pregnant rats and then administered AFSC-EVs to the fetuses before birth, comparing their lung function and morphology to control pups that didn't receive the treatment.
- Results showed that pups treated with AFSC-EVs had improved lung mechanics, structure, and reduced collagen deposition compared to those treated with saline, suggesting potential therapeutic benefits for managing CDH-related lung impairment in neonates.