Publications by authors named "M L Beach"
The oral cavity is a critical barrier with immunosurveillance capabilities. A detailed understanding of its cellular, molecular, and spatial architecture is essential for advancing precision medicine across aerodigestive tissues. Here, we present the first integrated atlas of human adult oral and craniofacial tissues, derived from single-cell RNA sequencing of ~250,000 cells from 70 samples across 13 niches, including salivary glands and oral mucosae.
View Article and Find Full Text PDFAutoantibodies are important for the diagnosis of autoimmune interstitial lung disease (ILD). Standard immunoassays have limitations, including their qualitative nature and/or a narrow dynamic range of detection, hindering the usefulness of autoantibodies as biomarkers of disease activity. Here, the luciferase immunoprecipitation system (LIPS) was evaluated for measuring myositis-specific and other lung-related autoantibodies in 25 subjects with idiopathic inflammatory myopathies (IIM), 26 with Sjögren's disease (SjD), and 10 healthy volunteers.
View Article and Find Full Text PDFArticle Synopsis
- This study aimed to create a comprehensive consensus on managing myopia in children and young people across the UK and Ireland through a Delphi method involving 34 expert optometrists and ophthalmologists.
- The panel agreed on 131 statements, emphasizing the need for parental discussions on interventions for myopia developed before age 13, publicly funded options for those at risk, and the consideration of individual hobbies and lifestyles in choosing treatment.
- Future research is essential to better identify at-risk patients, assess the effectiveness of treatments, and adapt management strategies as new evidence arises.