Publications by authors named "M L Bazzo"
SARS-CoV-2 Genomic Variants and Their Relationship with the Expressional and Genomic Profile of Angiotensin-Converting Enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2).
Microorganisms
November 2024
Over the past four years, angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) have been extensively studied, given their important role in SARS-CoV-2 replication; however, most studies have failed to compare their behavior in the face of different SARS-CoV-2 genomic variants. Therefore, this study evaluated the influence of different variants in ACE2/TMPRSS2 expressional and genomic profiles. To achieve this, 160 nasopharyngeal samples, previously detected with SARS-CoV-2 via RT-qPCR (June 2020-July 2022), were quantified for ACE2/TMPRSS2 expression levels, also using RT-qPCR; SARS-CoV-2 genomic variants, along with polymorphisms in the ACE2/TMPRSS2 coding genes, were identified using nanopore sequencing.
View Article and Find Full Text PDFObjective: To investigate the prognostic significance of thyroid hormone profile in patients hospitalized for decompensated cirrhosis.
Subjects And Methods: Prospective cohort study that included 119 subjects. All subjects were evaluated at admission and followed for 90 days.
Article Synopsis
- - The study aimed to determine the prevalence and contributing factors of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections in transgender women and travestis across five Brazilian cities from 2019 to 2021.
- - A total of 1,297 participants were analyzed, revealing CT prevalence at 11.5%, NG at 13.3%, and coinfection at 3.6%, with certain factors like sex work and injectable drug use significantly linked to higher infection rates.
- - The findings highlight that transgender individuals, especially younger ones involved in sex work and illicit drug use, experience greater prevalence of sexually transmitted infections compared to the general population.
During the SARS-CoV-2 pandemic angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) were constantly under the scientific spotlight, but most studies evaluated ACE2 and TMPRSS2 expression levels in patients infected by SARS-CoV-2. Thus, this study aimed to evaluate the expression levels of both proteins before, during, and after-infection. For that, nasopharyngeal samples from 26 patients were used to measure ACE2/TMPRSS2 ex-pression via qPCR.
View Article and Find Full Text PDFObjectives: Regular quality-assured WGS with antimicrobial resistance (AMR) and epidemiological data of patients is imperative to elucidate the shifting gonorrhoea epidemiology, nationally and internationally. We describe the dynamics of the gonococcal population in 11 cities in Brazil between 2017 and 2020 and elucidate emerging and disappearing gonococcal lineages associated with AMR, compare to Brazilian WGS and AMR data from 2015 to 2016, and explain recent changes in gonococcal AMR and gonorrhoea epidemiology.
Methods: WGS was performed using Illumina NextSeq 550 and genomes of 623 gonococcal isolates were used for downstream analysis.