Publications by authors named "M L BOZZI"
Early osteointegration in "one-step" resection and reconstruction using porous hydroxyapatite custom implants for skull-infiltrating tumors: a monocentric prospective series.
Acta Neurochir (Wien)
November 2024
Background: Early reconstruction of the skull represents the gold standard after resection of bone infiltrating cranial tumors. Customized hydroxyapatite porous ceramics are an excellent option for covering skull bone defects. The authors illustrate the surgical technique and investigate the effectiveness of the "one-step" procedure in terms of aesthetic results and early degree of osteointegration.
View Article and Find Full Text PDFPrevious studies have shown that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with increased stress fracture risk. This phenomenon has been studied predominantly in high-activity individuals, so data regarding the general population are limited despite the substantial economic and resource burden of stress fracture injuries within the general US population. Furthermore, our preclinical studies demonstrate that regular use of NSAIDs also diminishes the intrinsic ability of bone to resist fracture.
View Article and Find Full Text PDFArticle Synopsis
- Pure germinoma is a rare brain tumor that usually starts in the middle of the brain; sometimes it can be found in two places at once or outside the usual spots, which is very uncommon.
- Researchers reviewed many studies to look at how doctors diagnose and treat patients with these rare brain tumors and to find ways to help them faster.
- The review showed that most patients needed a biopsy (taking a small sample for testing), and many had these tumors in unusual places, which can make it hard to find and treat them quickly.
Article Synopsis
- Dystroglycan (DG) is a receptor made up of α- and β-DG subunits, and a specific mutation in the β-DG subunit is linked to muscle-eye-brain disease in humans.
- In a mouse model with this mutation, many embryos do not survive to term, but those that do show normal early development but later develop muscle issues and changes in protein localization affecting the blood-brain barrier.
- The mutant mice have reduced levels of DG proteins in muscle and brain, making them a valuable model for studying the effects of β-DG alterations and the underlying mechanisms of a related disease.