Evaluation of SB-83, a 2-amino-thiophene derivative, against Leishmania species that cause visceral leishmaniasis.

Visceral leishmaniasis is a systemic disease that affects various internal organs and represents the most severe and fatal form of leishmaniasis. Conventional treatment presents significant challenges, such as prolonged management in hospital settings, high toxicity, and an increasing growing number of cases of resistance. In previous studies, our research group demonstrated the effective and selective activity of the 2-amino-thiophene derivative SB-83 in preclinical models of cutaneous leishmaniasis.

Processed Food Consumption and Sleep Quality in School-Aged Children: Insights from a Cross-Sectional Study.

Objective: This cross-sectional study aimed to investigate the association between processed food consumption and sleep quality among school-aged children.

Methods: Our sample consisted of 137 children, with 52.6% being girls with a mean age of 7.

(-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective Mechanisms.

Background: (-)-Fenchone is a bicyclic monoterpene present in the plant species Mill, L. (tuja), and (lavender). These plants have therapeutic value in the treatment of intestinal disorders.

Correlation of Solidification Thermal Variables with Microstructure and Hardness in CuMn11Al8Fe3Ni3 Manganese-Aluminum-Bronze Alloy.

The mechanical properties of a final product are directly influenced by the solidification process, chemical composition heterogeneity, and the thermal variables during solidification. This study aims to analyze the influence of solidification thermal variables on the microstructure, hardness, and phase distribution of the CuMn11Al8Fe3Ni3. The alloy was directionally and upward solidified from a temperature of 1250 °C.

Improves Survival of and Mice During Lethal Infection with .

: is a vegetal species popularly used to treat fungal infections. This study evaluated the anti- effect of extract after lethal infection in larvae and mice. : The chemical profile analysis of a hydroethanolic extract of the leaves of (EHVG) identified 14 compounds.