Toxic epidermal necrolysis caused by vemurafenib in a metastatic malignant melanoma.

Combination targeted therapy with vemurafenib and cobimetinib has proved effective for metastatic melanoma. However, severe cutaneous adverse reactions have been reported, most frequently not only drug rash with eosinophilia and systemic syndrome but also rare Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN) cases. We report a case of life-threatening episode of TEN following metastatic melanoma targeted therapy with vemurafenib and cobimetinib, with a long but successful patient recovery.

A contextual-compositional approach to discover associations between health determinants and health indicators for neonatal mortality rate monitoring in situations of anomalies.

Introduction: Epidemiology is considered both a field of research and a methodological approach within the broader health sciences. It aims to understand health-related events' causes and effects and provide the evidence necessary to prevent disease and implement effective control and prevention strategies. One of the main focuses of epidemiology is identifying the determinant factors in the health situation of populations since health-related anomalies are not randomly distributed among people.

Interpersonal violence in the state of Espírito Santo: analysis of mandatory notifications between 2011 and 2018.

Objective: To identify the frequency of notifications of interpersonal violence in Espírito Santo from 2011 to 2018, and the factors associated with this issue.

Methods: This is a cross-sectional study in which all cases of interpersonal violence from the Information System for Notifiable Diseases in the state of Espírito Santo during the period from 2011 to 2018 were analyzed. Absolute and relative frequencies and 95% confidence intervals were calculated, as well as Poisson regression.

Body composition and phase angle in rugby union athletes: A comparison between forward and back positions.

Introduction: Rugby union has been increasingly attracting a multitude of enthusiasts over the past years. Nevertheless, there is a need for a more profound understanding of body composition, particularly regarding body fluids, and phase angle by playing position in rugby union athletes.

Methods: This study aimed to compare body composition components and phase angle among rugby union athletes based on their playing positions (forwards vs.

Adherence to Exercise in People with Lung or Head and Neck Cancer: Self-Reported Symptoms and Motivation During Cancer Treatment Need to Be Considered.

: Symptoms and motivation may impact adherence to home-based exercise training programs (HETP) during cancer treatment (CT) for lung or head and neck cancer. This study aimed to identify self-reported symptoms and their frequency, as well as motivation towards an HETP during CT for primary lung or head and neck cancer. Associations between symptoms and motivation with HETP adherence were also investigated.