Publications by authors named "M Kysela"
Background: Lung cancer (LC) represents the leading cause of cancer-related deaths in the Czech Republic. Over the past decade, there have been notable advancements in LC treatment based on findings from controlled clinical trials (CTs). However, patients enrolled in CTs may not fully represent the diversity of real-world patient populations from routine clinical practice.
View Article and Find Full Text PDFIntroduction: Gastric and gastroesophageal junction adenocarcinoma is a disease with high mortality. Approximately 10% of these tumors are characterized by microsatellite instability with a presumed good response to immunotherapy. So far, treatment with checkpoint inhibitors is part of palliative regimens, in the Czech Republic this treat-ment is reimbursed in patients with MSI-H gastroesophageal adenocarcinoma exhibiting a combined positive score ≥ 5.
View Article and Find Full Text PDFSkeletal Muscle P MR Spectroscopy Surpasses CT in Predicting Patient Survival After Liver Transplantation.
J Cachexia Sarcopenia Muscle
February 2025
Article Synopsis
- Patients with liver cirrhosis may face higher risks of severe outcomes after liver transplantation (LT) due to skeletal muscle changes, like sarcopenia and myosteatosis.
- A study analyzed 134 LT candidates, using CT scans and phantom MR spectroscopy (MRS) of calf muscles to assess muscle alterations and their effects on surgical outcomes and long-term survival.
- Results revealed that patients with abnormal MRS and CT-diagnosed myosteatosis had significantly worse long-term survival and higher surgical complications, indicating that these muscle changes can be critical indicators for post-transplant prognosis.
Background: While 4 randomized controlled clinical trials confirmed the early benefits of hypothermic oxygenated machine perfusion (HOPE), high-level evidence regarding long-term clinical outcomes is lacking. The aim of this follow-up study from the HOPE-ECD-DBD trial was to compare long-term outcomes in patients who underwent liver transplantation using extended criteria donor allografts from donation after brain death (ECD-DBD), randomized to either HOPE or static cold storage (SCS).
Methods: Between September 2017 and September 2020, recipients of liver transplantation from 4 European centers receiving extended criteria donor-donation after brain death allografts were randomly assigned to HOPE or SCS (1:1).
Background: We aimed to screen Ukrainian war refugees (UWR) in Czechia for depression and anxiety, and to assess their recognition of personal mental health problems and related help-seeking.
Methods: We conducted a cross-sectional study on a sample of UWR in Czechia. We used PHQ-8 and GAD-7 to screen for depression and anxiety, SELF-I to assess the recognition of respondents' own mental health problems, and a set of questions regarding mental health-related help-seeking.