Publications by authors named "M Kvandova"
Background: Epidemiology links noise to increased risk of metabolic diseases like diabetes and obesity. Translational studies in humans and experimental animals showed that noise causes reactive oxygen species (ROS)-mediated cardiovascular damage. The interaction between noise and diabetes, specifically potential additive adverse effects, remains to be determined.
View Article and Find Full Text PDFCardiovascular diseases (CVDs) are the leading cause of mortality and disability among both males and females. The risk of cardiovascular diseases is heightened by the presence of a risk factor cluster of metabolic syndrome, covering obesity and obesity-related cardiometabolic risk factors such as hypertension, glucose, and lipid metabolism dysregulation primarily. Sex hormones contribute to metabolic regulation and make women and men susceptible to obesity development in a different manner, which necessitates sex-specific management.
View Article and Find Full Text PDFLarge epidemiological studies have shown that traffic noise promotes the development of cardiometabolic diseases. It remains to be established how long these adverse effects of noise may persist in response to a noise-off period. We investigated the effects of acute aircraft noise exposure (mean sound level of 72 dB(A) applied for 4d) on oxidative stress and inflammation mediating vascular dysfunction and increased blood pressure in male C57BL/6 J mice.
View Article and Find Full Text PDFArticle Synopsis
- Environmental stressors like traffic noise contribute to a significant loss of healthy life years and require effective prevention strategies to address health impacts, especially related to vascular dysfunction.
- In a study using mice exposed to aircraft noise, various methods of activating α1AMPK—through pharmacological means, exercise, and intermittent fasting—were found to prevent endothelial dysfunction and oxidative stress caused by the noise exposure.
- The findings suggest that activating α1AMPK specifically in endothelial cells can protect against noise-induced vascular damage, highlighting the need for further research to evaluate these interventions in human populations.
The prevalence and clinical importance of arterial hypertension are still growing. Inorganic nitrite (NO) represents an attractive dietary antihypertensive agent, but its metabolism and mode of action, which we aimed to investigate with the present study, are not completely understood. Isolated aortic rings from rats were treated ex vivo with oxidants, and rats were infused in vivo with angiotensin-II.
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