Publications by authors named "M Kuwabara"
Intravascular ultrasound (IVUS) has become a standard procedure for performing coronary intervention, but its impact on peripheral endovascular therapy (EVT) remains unclear. To assess the usefulness of IVUS during EVT, this study analyzed over 2000 consecutive patients from the TOkyo-taMA peripheral vascular intervention research COmraDE (TOMA-CODE) registry with peripheral arterial disease (PAD) in Japan. The primary outcome was chronic limb events (a composite of clinically driven target lesion revascularization (cTLR) and major amputation) during a two-year follow-up period.
View Article and Find Full Text PDFBackground: Thrombectomy for acute large vessel occlusion is a well-established treatment for stroke prevention. However, futile recanalization cases, where no-reflow occurs despite successful recanalization, have been reported. This study aimed to assess cerebral hemodynamics immediately after thrombectomy and their relationship with clinical outcomes.
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- Uric acid, produced from purine metabolism, is linked to hypertension and cardiovascular disease (CVD), with new studies emerging recently highlighting its impact.
- Recent research indicates that hyperuricemia, caused by factors like diet and genetics, may contribute to various health issues including hypertension, kidney disease, and sleep disorders.
- The exact causal relationship between hyperuricemia, inflammation, and oxidative stress remains uncertain, emphasizing the need for more research to understand its role in CVD and to improve treatment options.
Varicose veins are common lower extremity venous disorders characterized by dilated veins and incompetent valves. Although maintaining the required vein wall tone for adaptive responses depends on a proper contractile function of the human saphenous smooth muscle, the contractile properties of varicose veins are mostly unknown. We investigated the relationship between contractile responses and the internal diameter of human saphenous varicose veins.
View Article and Find Full Text PDFCancer and cardiovascular disease (CVD) are the leading causes of death in Japan, with an increasingly recognized interrelationship. Both diseases share numerous risk factors and pathophysiological mechanisms, suggesting a bidirectional influence on onset and progression. Recent studies reveal that cancer survivors face elevated CVD risks, particularly shortly after diagnosis, while CVD may predispose individuals to cancer.
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