Publications by authors named "M Kusche-Gullberg"
Novel roles for cooperating collagen receptor families in fibrotic niches.
Curr Opin Cell Biol
December 2023
Article Synopsis
- Recent studies show that special proteins called collagen receptors work together in the tough areas around tumors, known as fibrosis or fibrotic niches.
- In some tumors, DDR1 helps control how cancer cells interact with a collagen type called collagen III, affecting whether they stay inactive or spread to other parts of the body.
- The study highlights the importance of understanding how these collagen receptors work together to improve treatments targeting tumors and their surrounding environments.
Article Synopsis
- * The study revealed that HS on melanoma cells attracts von Willebrand factor (vWF), forming a complex that can hinder cancer cells from adhering to blood vessels, thus potentially reducing their ability to spread via the bloodstream.
- * Experiments showed that melanoma cells with lower levels of HS were more likely to evade detection by vWF, leading to increased metastasis, which was further supported by tissue analyses from melanoma patients indicating lower HS production in metastatic cells.
There is currently an increased interest in understanding the role of the tumor microenvironment (TME) in tumor growth and progression. In this context the role of integrins in cancer-associated fibroblasts (CAFs) will need to be carefully re-evaluated. Fibroblast-derived cells are not only in the focus in tumors, but also in tissue fibrosis as well as in inflammatory conditions.
View Article and Find Full Text PDFNDST1 (glucosaminyl N-deacetylase/N-sulfotransferase) is a key enzyme in heparan sulfate (HS) biosynthesis, where it is responsible for HS N-deacetylation and N-sulfation. In addition to the full length human enzyme of 882 amino acids, here designated NDST1A, a shorter form containing 825 amino acids (NDST1B) is synthesized after alternative splicing of the NDST1 mRNA. NDST1B is mostly expressed at a low level, but increased amounts are seen in several types of cancer where it is associated with shorter survival.
View Article and Find Full Text PDFHeparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation.
Biochim Biophys Acta Gen Subj
May 2019
One of the main feature of chronic kidney disease is the development of renal fibrosis. Heparan Sulfate (HS) is involved in disease development by modifying the function of growth factors and cytokines and creating chemokine gradients. In this context, we aimed to understand the function of HS sulfation in renal fibrosis.
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