Publications by authors named "M Kusaoi"
Article Synopsis
- Granulocyte/monocyte adsorption therapy can help treat mild-to-moderate inflammatory bowel disease by removing activated immune cells, and its efficacy was tested using new columns designed for better adsorption.
- In a study with rats suffering from colitis, the new columns led to improved tissue health but didn’t significantly enhance the rate of immune cell adsorption into the blood.
- The therapy was associated with an increase in newly formed B cells that produced higher levels of interleukin-10, suggesting they play a role in reducing inflammation and controlling colitis symptoms.
Type I interferons (IFN-Is) play a significant role in systemic lupus erythematosus (SLE) pathogenesis. Double-filtration plasmapheresis (DFPP) is a treatment option for SLE; however, its effect on IFN-Is remains unclear. Therefore, we investigated the effects of DFPP on IFN-Is.
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- Enhanced IFNα production is linked to the development of systemic lupus erythematosus (SLE), particularly through the activation of the STING pathway in monocytes from SLE patients.
- Research showed that SLE monocytes exhibited increased expression of GATA4, which elevates IFNα production and is associated with markers of cellular senescence like CDKN2A.
- The study concluded that GATA4 plays a crucial role by binding to the enhancer regions of IFIT genes, thereby boosting the production of type I interferons, which are elevated in the context of SLE.
Introduction: To control the spread of severe disease caused by mutant strains of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), it is necessary to determine whether continued vaccination enhances humoral and cellular immunity.
Aim: In this study, we examined the changes in humoral and cellular immunity to SARS-CoV-2 after administration of the third vaccination in Japanese adults who had received the second dose of messenger ribonucleic acid (mRNA)-1273 vaccine and the third vaccination (BNT162b2 or mRNA-1273).
Methods: We measured anti-spike antibodies in immunoglobulin G (IgG) and anti-nucleocapsid IgG titers in the serum of the vaccinated subjects.
Article Synopsis
- The classical pathway of the complement activation system is known to be important in systemic lupus erythematosus (SLE), but the role of the lectin pathway, particularly involving MASPs, was previously unclear.
- This study examined serum levels of MASP-1 and MASP-2 in 68 SLE patients, categorized into those with membranous lupus nephritis (M-LN), proliferative lupus nephritis (P-LN), and those without nephritis (non-LN).
- Results indicated that MASP levels were significantly decreased in both P-LN and non-LN patients, while those in M-LN patients remained unchanged, suggesting that the lectin pathway is crucial to SLE pathogenesis except