Publications by authors named "M Kurzawski"

Article Synopsis
  • The study investigates the prevalence of immune evasion (IE) genes in 86 strains of methicillin-susceptible Staphylococcus aureus (MSSA) collected from outpatients, highlighting the role of these genes in the pathogen's ability to evade the immune system.
  • Researchers utilized polymerase chain reaction to detect IE genes and pulsed-field gel electrophoresis (PFGE) to analyze the clonal relatedness of the strains.
  • Findings revealed that the majority of strains possessed multiple IE genes, with IEC type F being the most common, indicating a diverse genetic repertoire that allows these strains to effectively avoid host immune responses.
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Herein, we report the results of anticancer screening of two 2-phenylbenzo[b]furan derivatives functionalised at the 3-position with 4-hydroxy-3,5-dimethoxybenzoyl (BF2) or 3,4,5-trimethoxybenzoyl (BF3) against 60 different cancer cell lines. The results confirmed the anticancer potential of the tested compounds against different cancer cell types, especially colon cancer, brain cancer and melanoma. BF3 was defined as the most potent (also as a tubulin polymerisation inhibitor).

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Background: The gene encodes the enzyme catechol-O-methyltransferase, which is a key modulator of dopaminergic and adrenergic neurotransmission. Hip osteoarthritis is accompanied by reduced mobility and some level of disability. In our study, we analyzed the association between some gene polymorphisms and reduced mobility in patients after total hip replacement (THR).

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Increasing alcohol consumption by women of childbearing age contributes to more frequent cases of fetal alcohol spectrum disorder. The cause of the syndrome is fetal alcohol exposure, particularly what is referred to as high prenatal alcohol exposure. Low metabolic activity of fetal enzymes shifts the burden of ethanol removal to maternal metabolism.

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Background: Cadmium (Cd) and lead (Pb) are heavy metals with carcinogenic potential. Their increased concentration has been correlated with a risk of malignancies, including breast, lung, kidney, gastrointestinal, and gynecological cancers. Most of the studies have evaluated tissue heavy metal concentration.

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