Publications by authors named "M Kuro-o"
Background And Objective: In acute kidney injury (AKI), a strong inflammatory component is activated in response to the renal damage, and one of the main mediators behind this process is the pro-inflammatory interleukin 6 or IL-6. Beside to this phenomenon, there are also alterations in different components of mineral metabolism, such as those dependent on fibroblast growth factor (FGF)23 and the anti-ageing cofactor klotho. The aim of this work was to explore the association between renal function and systemic levels of IL-6, as well as FGF23 and klotho in the early stages of AKI, analysing the predictive capacity of IL-6 in early mortality associated with AKI.
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- - The study investigates the levels of soluble αKlotho, a protein linked to aging, found in blood, particularly focusing on its origin from the kidneys.
- - Blood samples were taken from patients during adrenal venous catheterization to measure αKlotho levels in different sections of the inferior vena cava.
- - Results showed higher αKlotho concentrations above the kidneys (suprarenal) compared to below (infrarenal), indicating that the kidneys significantly contribute to αKlotho levels in the bloodstream.
Article Synopsis
- Hemodialysis patients respond differently to vaccines, exhibiting less antibody response and varied vaccine dosing, prompting a study on their antibody glycosylation profiles following vaccination and infection with SARS-CoV-2.
- The research involved analyzing plasma samples from 112 hemodialysis patients across four groups: control, infected, vaccinated, and those infected post-vaccination, along with examining samples before and after a booster dose.
- Results showed both vaccination and infection resulted in reduced fucosylation of IgG1 (indicating inflammation), while vaccination increased anti-inflammatory markers like galactosylation, highlighting the need to consider antibody glycosylation when assessing vaccine efficacy and development.
Article Synopsis
- Recent studies have shown that higher levels of blood calciprotein particles (CPP) are linked to vascular calcification and cardiovascular issues in patients on hemodialysis, despite varying levels among individuals with similar phosphorus levels.
- This study examined whether the ratio of serum CPP to serum phosphate (CPP/Pi ratio) could better predict cardiovascular events compared to traditional calcification tests (T) in 174 new hemodialysis patients.
- Results indicated that the CPP/Pi ratio was a significant independent predictor of major heart and brain-related events, whereas traditional calcification propensity tests did not show a similar association.
Article Synopsis
- The study investigates the link between elevated phosphate concentrations in the proximal tubule, serum FGF23 levels, and kidney damage in middle-aged individuals with mild chronic kidney disease (CKD).
- Involving 218 participants aged 45 and older, researchers measured various health indicators and found that as CKD progresses, levels of ePTFp, serum FGF23, and markers of kidney damage all increased, although phosphate concentrations remained stable.
- The findings suggest that higher ePTFp correlates strongly with increased serum FGF23 and kidney damage biomarkers, supporting previous mouse studies and indicating potential mechanisms of kidney injury in humans with CKD.