Publications by authors named "M Kurachi"
Primary cardiac lymphoma is a rare disease with the potential to be fatal. This case reports a patient who developed primary cardiac lymphoma resulting in cardiac tamponade. Despite a compromised general condition, the lymphoma was diagnosed through a transvenous tumor biopsy.
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- Exhausted CD8 T cells in chronic viral infections and cancer express inhibitory receptors (IRs) like PD-1, which can be blocked to reinvigorate T cell function.
- Co-targeting multiple IRs, such as PD-1 and LAG-3, can enhance T cell response and disease control beyond blocking PD-1 alone.
- The study reveals distinct functions of PD-1 and LAG-3 in T cell activity, showing LAG-3's role in T cell durability and in creating a subset of T cells that are more effective at killing cancer or infected cells.
Rewiring exhausted CD8 T (Tex) cells toward functional states remains a therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor Tox. However, epigenetic remodeling occurs as Tex cells transition from progenitor (Tex) to intermediate (Tex) and terminal (Tex) subsets, suggesting development flexibility.
View Article and Find Full Text PDFFeasibility and reliability of the pandemic-adapted online-onsite hybrid graduation OSCE in Japan.
Adv Health Sci Educ Theory Pract
July 2024
Objective structured clinical examination (OSCE) is widely used to assess medical students' clinical skills. Virtual OSCEs were used in place of in-person OSCEs during the COVID-19 pandemic; however, their reliability is yet to be robustly analyzed. By applying generalizability (G) theory, this study aimed to evaluate the reliability of a hybrid OSCE, which admixed in-person and online methods, and gain insights into improving OSCEs' reliability.
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- Epithelial tissue plays a key role in innate immunity by recognizing and eliminating pathogens, with the Met receptor being crucial for epithelial cell survival and regeneration.
- The study found that Met is essential for triggering cytokine production in response to nonself double-stranded RNA, even though its tyrosine kinase activity is not needed for this process.
- Instead, Met's intracellular carboxy terminus interacts with MAVS to enhance antiviral signaling, highlighting its dual role in supporting both cell regeneration and immune responses in epithelial cells.