Publications by authors named "M Kunz"
A virtual patient authoring tool for transcatheter aortic valve replacement.
Int J Comput Assist Radiol Surg
December 2024
Purpose: Computer-based medical training scenarios, derived from patient's records, often lack variability, modifiability, and availability. Furthermore, generating image datasets and creating scenarios is resource-intensive. Therefore, patient authoring tools for rapid dataset-independent creation of virtual patients (VPs) is a pressing need.
View Article and Find Full Text PDFThe oral cavity is a critical barrier with immunosurveillance capabilities. A detailed understanding of its cellular, molecular, and spatial architecture is essential for advancing precision medicine across aerodigestive tissues. Here, we present the first integrated atlas of human adult oral and craniofacial tissues, derived from single-cell RNA sequencing of ~250,000 cells from 70 samples across 13 niches, including salivary glands and oral mucosae.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed the proteomic profiles of 79 bladder cancer samples, categorizing them into non-muscle-invasive (NMIBC), muscle-invasive (MIBC), and neoadjuvant-treated MIBC groups.
- MIBC showed significant changes in the extracellular matrix and immune response-related proteins, as well as a decrease in proteins related to cell adhesion and lipid metabolism compared to NMIBC.
- The research identified multiple proteomic subgroups within MIBC and NMIBC that correlate with tissue type and metabolic pathways, revealing complex tumor-stroma interactions and significant genomic alterations in the cancers.
Background: Renal denervation lowers blood pressure (BP) in patients with uncontrolled hypertension. We conducted an unbiased genomic screen to identify genetic variants that may associate with BP response to renal denervation (RDN).
Methods: Patients (n=268) with uncontrolled resistant hypertension (baseline BP, 166±21/90±15 mm Hg) who underwent endovascular RDN using the Symplicity catheter (Medtronic, Inc, Santa Rosa, CA) were included.