Publications by authors named "M Kukla"
Brain plasticity is at the basis of many cognitive functions, including learning and memory. It includes several mechanisms of synaptic and extrasynaptic changes, neurogenesis, and the formation and elimination of synapses. The plasticity of synaptic transmission involves the expression of immediate early genes (IEGs) that regulate neuronal activity, thereby supporting learning and memory.
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- Endoscopic ablation is the primary treatment for dysplastic Barrett's esophagus (BE), primarily utilizing radiofrequency ablation (RFA) and argon plasma coagulation (APC) in Polish medical centers.
- A retrospective analysis of 160 adult patients revealed high rates of complete remission for intestinal metaplasia (80.0%) and dysplasia (93.8%), alongside a manageable adverse event rate, with 30.6% reporting minor and 5.6% major complications.
- The study also identified that RFA, used more for severe cases, had a higher failure rate compared to APC/h-APC, particularly in patients with long-segment BE and diabetes, suggesting specific risk factors for less favorable treatment outcomes
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- The study aimed to investigate chemerin levels as a potential marker for diagnosing early-stage hepatocellular carcinoma (HCC) and determining its severity.
- The research included 76 patients, with 45 diagnosed with HCC (some having single lesions and others with metastasis) and 21 with isolated cirrhosis, alongside a control group of 10 healthy individuals.
- Results showed that chemerin levels were higher in patients with HCC compared to those with cirrhosis only and tended to decrease with worsening liver function, indicating its potential use in HCC diagnosis and staging.
Respiratory viruses are among the most common causes of human infections. Examining pathological processes linked to respiratory viral infections is essential for diagnosis, treatment strategies, and developing novel therapeutics. Alterations in oxidative stress levels and homeostasis are significant processes associated with respiratory viral infections.
View Article and Find Full Text PDF: The COVID-19 pandemic has posed significant global health challenges. Despite extensive research efforts, the inflammatory response triggered by SARS-CoV-2 remains to be further explored and understood. Our study aims to examine the changes in serum concentrations of pro-inflammatory adipokines-visfatin and leptin-in COVID-19 patients in relation to a healthy control group.
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