Staged Screening Identifies People with Biomarkers Related to Neuronal Alpha-Synuclein Disease.

Objective: Remote identification of individuals with severe hyposmia may enable scalable recruitment of participants with underlying alpha-synuclein aggregation. We evaluated the performance of a staged screening paradigm using remote smell testing to enrich for abnormal dopamine transporter single-photon emission computed tomography imaging (DAT-SPECT) and alpha-synuclein aggregation.

Methods: The Parkinson's Progression Markers Initiative (PPMI) recruited participants for the prodromal cohort who were 60-years and older without a Parkinson's disease diagnosis.

Coevolution of marine phytoplankton and Alteromonas bacteria in response to pCO2 and coculture.

As a result of human activity, Earth's atmosphere and climate are changing at an unprecedented pace. Models based on short-term experiments predict major changes will occur in marine phytoplankton communities in the future ocean, but rarely consider how evolution or interactions with other microbes may influence these changes. Here, we experimentally evolved several phytoplankton in coculture with a heterotrophic bacterium, Alteromonas sp.

Cost of treating severe malaria in children in Africa: a systematic literature review.

Background: Malaria is a major cause of ill health and death in children in Africa. The disease also imposes a severe social and economic burden on households and health systems and is strongly associated with poverty. This study summarizes the most up-to-date cost of treating severe malaria in children in Africa.

Glyphosate formulations cause mortality and diverse sublethal defects during embryonic development of the amphibian Xenopuslaevis.

The human impact on environmental landscapes, such as land use, climate change or pollution, is threatening global biodiversity and ecosystems maintenance. Pesticides like the herbicide glyphosate have garnered considerable attention due to their well-documented harmful effects on non-target species. During application, the active ingredient glyphosate is utilized in various formulations, each containing different additive adjuvants.

Anoxic seagrass leaf environments as potential hotspots for toxin production and NO emission.

Epiphytes on seagrass leaves can render parts of the leaf phyllosphere anoxic in darkness owing to leaf/epiphyte respiration and O diffusion constraints. In such anoxic microenvironments, anaerobic microbes can potentially produce phytotoxins and greenhouse gases, but the actual occurrence of such processes in seagrass epiphytic biofilms remain uncertain. We used microsensors to measure O, NO, NO and HS concentration gradients, as well as NO and O dynamics within epiphytic biofilms on seagrass (Zostera marina) leaves under changing environmental conditions.