Publications by authors named "M Kubasch"
Article Synopsis
- The study explores different models that consider how mixed social structures (like households and workplaces) affect epidemic outcomes but highlights a lack of focus on how the size distribution within these structures can influence intervention strategies.
- The research emphasizes the impact of teleworking on workplace size distribution, finding that strategies promoting telework based on workplace size can reduce epidemic size and peak more effectively than simple linear models.
- A simplified version of the SIR model is proposed to maintain accuracy in predicting epidemic growth while reducing complexity, offering promising results for designing effective social distancing strategies.
Purpose: To review the currently available literature on clinical autonomic tests of sudomotor function.
Methods: We searched PubMED/MEDLINE for articles on technical principles and clinical applications of sudomotor tests with a focus on their drawbacks and perspectives in order to provide a narrative review.
Results: The quantitative sudomotor axon reflex sweat test (QSART) is the most widely used test of sudomotor function.
The vasomotor axon reflex can be evoked in peripheral epidermal nociceptive C-fibers to induce local vasodilation. This neurogenic flare response is a measure of C-fiber functional integrity and therefore shows impairment in patients with small fiber neuropathy. Laser Doppler flowmetry (LDF) and laser Doppler imaging (LDI) are both techniques to analyze vasomotor small fiber function by quantifying the integrity of the vasomotor-mediated axon reflex.
View Article and Find Full Text PDFBackground: The mammalian target of rapamycin inhibitor everolimus is approved as an antitumor agent in advanced estrogen receptor-positive breast cancer. Surrogate bone marker data from clinical trials suggest effects on bone metabolism, but the mode of action of everolimus in bone biology remains unclear. In this study, we assessed potential bone-protective effects of everolimus in the context of osteotropic tumors.
View Article and Find Full Text PDFBackground: In Parkinson's disease (PD), alpha-synuclein accumulation in cutaneous autonomic pilomotor and sudomotor nerve fibers has been linked to autonomic nervous system disturbances even in the early stages of the disease. This study aims to assess the association between alpha-synuclein-mediated structural autonomic nerve fiber damage and function in PD, elucidate the role of neuropathy progression during the early disease stages, and test reproducibility and external validity of pilomotor function assessment using quantitative pilomotor axon-reflex test and sudomotor function quantitative direct and indirect test of sudomotor function.
Methods/design: A prospective controlled study will be conducted at four study sites in Europe and the USA.