Publications by authors named "M Krsek"
Background: Thymic neuroendocrine tumor as a cause of Cushing syndrome is extremely rare in children.
Case Presentation: We report a case of a 10-year-old girl who presented with typical symptoms and signs of hypercortisolemia, including bone fractures, growth retardation, and kidney stones. The patient was managed with oral ketoconazole, during which she experienced adrenal insufficiency, possibly due to either cyclic adrenocorticotropic hormone (ACTH) secretion or concurrent COVID-19 infection.
Adrenal insufficiency - causes and laboratory diagnosis.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
October 2024
Article Synopsis
- Adrenal insufficiency (AI) is a syndrome that can be classified as primary, due to damage to the adrenal glands, or secondary, caused by a lack of stimulation from the pituitary gland.
- Diagnosis involves clinical evaluation and various biochemical tests that measure hormone levels and assess adrenal function.
- Proper diagnosis and timely hormone replacement therapy are essential to manage AI and prevent serious complications like adrenal crises.
Article Synopsis
- An online survey of European thyroid specialists revealed that 28% believe thyroid hormone (TH) treatment may be appropriate for euthyroid patients with growing simple goiters, despite guidelines against this practice.
- There were significant regional differences in support for TH treatment, with only 7% in The Netherlands compared to 78% in the Czech Republic.
- Factors influencing the likelihood of recommending TH included the specialist's age and the historical iodine insufficiency of their region, while gender, country, and economic factors showed weak associations.
Treatment of Obesity with Thyroid hormones in Europe. Data from the THESIS* Collaboration.
J Endocrinol Invest
June 2024
Purpose: The use of thyroid hormones (TH) to treat obesity is unsupported by evidence as reflected in international guidelines. We explored views about this practice, and associations with respondent characteristics among European thyroid specialists.
Methods: Specialists from 28 countries were invited to a survey via professional organisations.
Article Synopsis
- - The study aimed to assess how European thyroid specialists view levothyroxine (LT4) treatment for euthyroid women with positive thyroid peroxidase antibodies (TPOAb) to improve fertility, as current evidence does not support this practice.
- - An international survey (THESIS) revealed that 42.8% of over 2,316 respondents believe LT4 might be indicated for these patients, with significant variation across countries, highlighting a range from 22.9% to 83.7% of positive responses.
- - Factors such as gender, age, and clinical experience influenced opinions; younger specialists and those who treat more thyroid patients were more likely to consider LT4, raising concerns about potential overtreatment risks in