Publications by authors named "M Krkavcova"
Article Synopsis
- Down syndrome (DS) is a leading cause of intellectual disability, prompting research into effective prenatal detection methods, particularly focusing on plasma microRNAs (miRNAs).
- This study analyzed 70 first-trimester plasma samples from pregnant women to evaluate the diagnostic potential of miRNAs, building on earlier findings that identified specific miRNAs in DS placentas.
- Despite initial promising results from a pilot study, a larger validation study using a more sensitive technique found no significant differences in miRNA profiles between samples from DS and euploid fetuses, suggesting plasma miRNA testing may not be suitable for non-invasive prenatal testing at this stage.
Objective: Molecular pathogenesis of Down syndrome (DS) is still incompletely understood. Epigenetic mechanisms, including miRNAs gene expression regulation, belong to potential influencing factors. The aims of this study were to compare miRNAs expressions in placentas with normal and trisomic karyotype and to associate differentially expressed miRNAs with concrete biological pathways.
View Article and Find Full Text PDFObjective: The aim of the study was to estimate genetic changes detected in ovarian and cervical cancer cells, in correlation with other available clinical and histopathological parameters, with impact upon cancer prognosis.
Design: Original article.
Setting: Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles University in Prague and General Teaching Hospital, Prague.
The aim of the study was to estimate genetic alterations detected in ovarian cancer cells in correlation with other available parameters of histopathological and clinical character and to find important relations with impacts on the cancer prognosis. Additionally, we wanted to compare methods for evaluating genetic changes. Sixty patients with ovarian cancer were included in the study.
View Article and Find Full Text PDFThe aim of the study was to estimate genetic alterations detected in ovarian and cervical cancer cells, in correlation with other available parameters of a histopathological and clinical character and to find the important associations and differences of both these tumor sites with diverse impacts on the cancer's prognosis. Sixty patients presenting with ovarian cancer and twenty patients manifesting cervical cancer were included in the study. The histological type and grade, MIB-1 and p53 were estimated.
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