Publications by authors named "M Krishnapriya"
Individualization of the Dosage Regimen of Erythropoietin is Crucial in End-stage Renal Disease Patients.
Saudi J Kidney Dis Transpl
September 2023
Article Synopsis
- The study aimed to analyze how erythropoietin is used in patients with end-stage renal disease and how factors like body weight and sex affect their response.
- A total of 120 patients were reviewed, with different dosing regimens for erythropoiesis-stimulating agents, and results showed that the once-weekly dose was significantly more effective than the others.
- Higher body mass index (BMI) was linked to better responses to the therapy, while no significant difference was found between sexes regarding their response to treatment.
Indian Ocean has been undergoing rapid warming in recent years, which increases the likelihood of Marine heatwave (MHW). MHWs are extreme warm ocean surface conditions in which temperature exceeds the 95th percentile for three or more consecutive days. We investigate MHW events occurred in Arabian Sea (AS) and Bay of Bengal (BoB) during pre-monsoon for 1982-2021 period, their impact on Chlorophyll-a (Chl-a) and net primary productivity (NPP).
View Article and Find Full Text PDFTo review the state of the art aspects and contemporary innovative drug delivery strategies, for the treatment of vitreoretinal diseases, their mechanism of action through ocular routes and their future perspectives. Scientific databases such as PubMed, Science Direct, Google scholar were used to obtain 156 papers for review. The keywords searched were vitreoretinal diseases; ocular barriers; intravitreal injections; nanotechnology; biopharmaceuticals.
View Article and Find Full Text PDFLigands with the polysaccharide headgroups have been recently reported by our group to possess enhanced interaction with asialoglycoprotein receptor (ASGPR) in silico as compared to ligands having galactose moieties. This enhanced interaction is a result of the polymer's backbone support in anchoring the ligand in a specific orientation within the bilayer. In this paper, we have attempted to provide an in vitro proof of concept by performing a comparative evaluation of polysaccharide and monosaccharide-based ligands.
View Article and Find Full Text PDFArticle Synopsis
- The study isolated three new sesquiterpenes (1-3) and six known analogues (4-9) from the plant Carpesium cernuum, determining their structures using advanced NMR and ECD techniques.
- The anti-leukemia effects of these compounds were tested on three different leukemia cell lines, revealing that compounds 1-3 displayed moderate cytotoxicity.
- Specifically, compound 2 showed promise as an anti-leukemia agent by inducing apoptosis through the downregulation of the Bcl-2 protein and activating caspase enzymes in K562 cells.