Publications by authors named "M Krbec"

It is commonly assumed that changes in plasma strong ion difference (SID) result in equal changes in whole blood base excess (BE). However, at varying pH, albumin ionic-binding and transerythrocyte shifts alter the SID of plasma without affecting that of whole blood (SID), i.e.

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Article Synopsis
  • The authors discuss two monozygotic male twins diagnosed with right-sided Legg-Calvé-Perthes disease (LCPD) who exhibit different formations of their lumbosacral junction.
  • While both twins were treated for LCPD during childhood, Twin A has a fusion of the L5 transverse process with the sacral ala, whereas Twin B has complete sacralization of the fifth lumbar vertebra.
  • Despite this morphological difference, the twins' treatment outcomes align with larger studies, indicating that the age of LCPD onset is crucial for prognosis.
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Background: Several studies explored the interdependence between Paco2 and bicarbonate during respiratory acid-base derangements. The authors aimed to reframe the bicarbonate adaptation to respiratory disorders according to the physical-chemical approach, hypothesizing that (1) bicarbonate concentration during respiratory derangements is associated with strong ion difference; and (2) during acute respiratory disorders, strong ion difference changes are not associated with standard base excess.

Methods: This is an individual participant data meta-analysis from multiple canine and human experiments published up to April 29, 2021.

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