Disulfide-Containing Nitrosoarenes: Synthesis and Insights into Their Self-Polymerization on a Gold Surface.

Disulfide-containing nitrosoarenes with [bis(4-nitrosobenzyl) disulfide, ()] or without [4-nitrosophenyl disulfide, (), and 1,2-bis(4'-nitroso-[1,1'-biphenyl]-4-yl)disulfane, ()] an alkyl spacer between the sulfur headgroup and the aromatic moiety (phenyl in () or biphenyl in ()) were synthesized and used as precursors to form azodioxy thiolate films on Au(111) substrates. Due to the incorporated disulfide functionalities, these specifically designed nitrosoarenes are enabled to self-polymerize through azodioxy bonds on a gold surface. Thin films of (), (), and () were prepared at different adsorption times via the solution-phase self-assembly of molecules onto the Au(111) surface and characterized by Raman spectroscopy, ellipsometry, water contact angle measurements, atomic force microscopy (AFM), and scanning tunneling microscopy (STM).

The Production of Water Kefir Drink with the Addition of Dried Figs in the Horizontal Rotating Tubular Bioreactor.

Water kefir is a product obtained through the fermentation of sucrose solution, usually with some kind of dried fruit addition, by a combined culture of micro-organisms which are contained within kefir grains. Its popularity is rising because of the simplicity of its preparation and its anti-inflammatory, antioxidant, probiotic, and antibacterial effects. In this research, the water kefir production was studied in 250 mL jars, as well as in a horizontal rotating tubular bioreactor (HRTB).

Assessment of the eutrophication status at Mediterranean sub-basin scale, within the European Marine Strategy Framework Directive.

The aim of this work is to define harmonized reference conditions and assessment thresholds for selected criteria elements of the Marine Strategy Framework Directive (MSFD) Descriptor 5 (Eutrophication) in the Eastern Mediterranean Sea and to test if a tool for integrated assessment of the status of marine systems can be used as a common methodological approach. In this frame, we tested two statistical approaches in order to set threshold values for four criteria of Descriptor 5: nutrients, chlorophyll a, transparency and dissolved oxygen in the bottom waters. It is noteworthy that this work revealed the need to apply common procedures in data treatment and assessment evaluation.

Design, Synthesis, Antitumor Activity and NMR-Based Metabolomics of Novel Amino Substituted Tetracyclic Imidazo[4,5-b]Pyridine Derivatives.

Newly prepared tetracyclic imidazo[4,5-b]pyridine derivatives were synthesized to study their antiproliferative activity against human cancer cells. Additionally, the structure-activity was studied to confirm the impact of the N atom position in pyridine nuclei as well as the chosen amino side chains on antiproliferative activity. Targeted amino substituted regioisomers were prepared by using uncatalyzed amination from corresponding chloro substituted precursors.

Design, Synthesis and Biological Activity of Novel Methoxy- and Hydroxy-Substituted -Benzimidazole-Derived Carboxamides.

This work presents the design, synthesis and biological activity of novel -substituted benzimidazole carboxamides bearing either a variable number of methoxy and/or hydroxy groups. The targeted carboxamides were designed to investigate the influence of the number of methoxy and/or hydroxy groups, the type of substituent placed on the N atom of the benzimidazole core and the type of substituent placed on the benzimidazole core on biological activity. The most promising derivatives with pronounced antiproliferative activity proved to be -methyl-substituted derivatives with hydroxyl and methoxy groups at the phenyl ring and cyano groups on the benzimidazole nuclei with selective activity against the MCF-7 cell line (IC = 3.