Publications by authors named "M Kraetzl"
Allogeneic intraportal islet transplantation (ITx) has become an established treatment for patients with poorly controlled type 1 diabetes. However, the loss of viable beta-cell mass after transplantation remains a major challenge. Therefore, noninvasive imaging methods for long-term monitoring of the transplant fate are required.
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- Growth hormone receptor deficiency (GHRD) leads to low levels of insulin-like growth factor 1 (IGF1) and high, non-functional growth hormone (GH) levels in both human Laron syndrome patients and animal models.
- A study compared pituitary glands from GHRD (GHR-KO) pigs and control pigs, finding that GHR-KO pigs had significantly lower body weights (60% reduction) and decreased pituitary volumes (54% reduction).
- Holistic proteome analysis revealed 4660 proteins, with 592 showing differences between GHR-KO and control groups, indicating changes in protein production and granule storage that contribute to the elevated serum GH levels observed in GHR-KO pigs
Neonatal porcine islet-like cell clusters (NPICCs) are a promising source for islet cell transplantation. Excellent islet quality is important to achieve a cure for type 1 diabetes. We investigated formation of cell clusters from dispersed NPICCs on microwell cell culture plates, evaluated the composition of re-aggregated porcine islets (REPIs) and compared function by transplantation into diabetic NOD-SCID IL2rγ (NSG) mice with native NPICCs.
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