Publications by authors named "M Koziolek"
Introduction: Gastrointestinal (GI) changes may alter drug absorption, potentially impacting both efficacy and safety of oral pharmacotherapy. However, the GI physiology is rarely studied in the aging population. This study aimed to explore GI transit time and pH in geriatric inpatients and older adults, and compare these findings with those from young volunteers.
View Article and Find Full Text PDFBackground: Patients with chronic heart failure (HF) show an increased risk for the occurrence of chronic kidney disease and cardiorenal syndrome. Urinary Dickkopf-3 (uDKK3), a stress-induced, tubular profibrotic glycoprotein, may be elevated in HF as early as in New York Heart Association class I HF and may indicate subsequent decline in estimated glomerular filtration rate (eGFR).
Methods And Results: uDKK3 levels in patients with HF and controls were measured by enzyme-linked immunosorbent assay.
Lipids in human intestinal fluids (HIF) form various structures, resulting in phase separation in the form of a lipid fraction and a micellar aqueous fraction. Currently used fed state simulated intestinal fluids (SIF) lack phase separation, highlighting the need for a deeper understanding of the effect of these fractions on intestinal drug solubilization in HIF to improve simulation accuracy. In this study, duodenal fluids aspirated from 21 healthy volunteers in fasted, early fed, and late fed states were used to generate 7 HIF pools for each prandial state.
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- Mineral abnormalities, including dyskalaemia, hyponatraemia, hypomagnesaemia, and iron deficiency, are common in heart failure (HF) and are linked to worse health outcomes and increased mortality rates.
- The imbalance in these minerals is influenced by factors like neurohumoral activation, effects of HF medications, and chronic conditions like kidney disease.
- Iron deficiency, affecting up to 60% of HF patients, is particularly serious, but iron replacement therapy has shown benefits, especially in patients with reduced and preserved ejection fractions.
Background: Cardiorenal syndrome is a common condition in clinical practice in which renal venous congestion (VC) plays an important role. Intrarenal Doppler ultrasound (IRD) is a non-invasive method to assess and quantify renal VC. The current study aims to investigate the effects of SGLT2 inhibitor (SGLT2i) therapy on IRD parameters of renal VC.
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