Publications by authors named "M Kotler"
Article Synopsis
- AID/APOBEC proteins, including APOBEC3G (A3G), are vital nucleic acid editors that play significant roles in immune response but can also trigger mutations that lead to cancer.
- The study shows that A3G helps repair double-strand breaks in DNA, helping transgenic mice survive lethal doses of radiation while wild-type mice do not.
- Research indicates that inhibiting A3G could improve cancer treatment effectiveness, while boosting its activity might alleviate symptoms from acute radiation exposure.
Human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G (hA3G), a member of the APOBEC family, was described as an anti-HIV-1 restriction factor, deaminating reverse transcripts of the HIV-1 genome. Several types of cancer cells that express high levels of A3G, such as diffuse large B-cell lymphoma cells and glioblastomas, show enhanced cell survival after ionizing radiation and chemotherapy treatments. Previously, we showed that hA3G promotes (DNA) double-strand breaks repair in cultured cells and rescues transgenic mice from a lethal dose of ionizing radiation.
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- In 2008, guidelines were established for researching autophagy, which has since gained significant interest and new technologies, necessitating regular updates to monitoring methods across various organisms.
- The new guidelines emphasize selecting appropriate techniques to evaluate autophagy while noting that no single method suits all situations; thus, a combination of methods is encouraged.
- The document highlights that key proteins involved in autophagy also impact other cellular processes, suggesting genetic studies should focus on multiple autophagy-related genes to fully understand these pathways.
A mutation in POLR3E impairs antiviral immune response and RNA polymerase III.
Proc Natl Acad Sci U S A
September 2020
RNA polymerase (Pol) III has a noncanonical role of viral DNA sensing in the innate immune system. This polymerase transcribes viral genomes to produce RNAs that lead to induction of type I interferons (IFNs). However, the genetic and functional links of Pol III to innate immunity in humans remain largely unknown.
View Article and Find Full Text PDFKinetic and protective role of autophagy in manganese-exposed BV-2 cells.
Biochim Biophys Acta Mol Cell Res
October 2020
Manganese (Mn) plays an important role in many physiological processes. Nevertheless, Mn accumulation in the brain can cause a parkinsonian-like syndrome known as manganism. Unfortunately, the therapeutic options for this disease are scarce and of limited efficacy.
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