Publications by authors named "M Kosel"
Background: Predictive performance of polygenic risk scores (PRS) varies across populations. To facilitate equitable clinical use, we developed PRS for coronary heart disease (CHD; PRS) for 5 genetic ancestry groups.
Methods: We derived ancestry-specific and multi-ancestry PRS based on pruning and thresholding (PRS) and ancestry-based continuous shrinkage priors (PRS) applied to summary statistics from the largest multi-ancestry genome-wide association study meta-analysis for CHD to date, including 1.
Background: Predictive performance of polygenic risk scores (PRS) varies across populations. To facilitate equitable clinical use, we developed PRS for coronary heart disease (PRS) for 5 genetic ancestry groups.
Methods: We derived ancestry-specific and multi-ancestry PRS based on pruning and thresholding (PRS) and continuous shrinkage priors (PRS) applied on summary statistics from the largest multi-ancestry genome-wide meta-analysis for CHD to date, including 1.
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation.
Nat Genet
June 2023
Article Synopsis
- * A large study identified 16 genetic risk factors for SCAD, highlighting potential genes involved in blood vessel function and the physical structure of arteries.
- * Some genetic variants linked to SCAD show opposing effects on CAD, suggesting that while both diseases share certain biological links, they operate through different pathways; high blood pressure was also found to possibly contribute to SCAD risk.
The healing of neuronal injuries is still an unachieved goal. Medicine-based therapies can only extend the survival of patients, but not finally lead to a healing process. Currently, a variety of stem cell-based tissue engineering developments are the subject of many research projects to bridge this gap.
View Article and Find Full Text PDF