Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants.

Somatic hypermutation (SHM) drives affinity maturation and continues over months in SARS-CoV-2-neutralizing antibodies (nAbs). However, several potent SARS-CoV-2 antibodies carry no or only a few mutations, leaving the question of how ongoing SHM affects neutralization unclear. Here, we reverted variable region mutations of 92 antibodies and tested their impact on SARS-CoV-2 binding and neutralization.

SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns.

SARS-CoV-2 neutralizing antibodies play a critical role in COVID-19 prevention and treatment but are challenged by viral evolution and the emergence of novel escape variants. Importantly, the recently identified Omicron sublineages BA.2.

Determining the reliability of rapid SARS-CoV-2 antigen detection in fully vaccinated individuals.

Background: Rapid antigen detection tests (RADT) are commonly used as SARS-CoV-2 diagnostic tests both by medical professionals and laypeople. However, the performance of RADT in vaccinated individuals has not been fully investigated.

Objectives: RT-qPCR and rapid antigen detection testing were performed to evaluate the performance of the Standard Q COVID-19 Ag Test in detecting SARS-CoV-2 breakthrough infections in vaccinated individuals.

No substantial preexisting B cell immunity against SARS-CoV-2 in healthy adults.

Preexisting immunity against SARS-CoV-2 may have critical implications for our understanding of COVID-19 susceptibility and severity. The presence and clinical relevance of a preexisting B cell immunity remain to be fully elucidated. Here, we provide a detailed analysis of the B cell immunity to SARS-CoV-2 in unexposed individuals.

Comprehensive analysis of Twitter usage during a major medical conference held virtually versus in-person.

Background: Twitter has become one of the most important social media platforms in science communication. During scientific conferences, Twitter can facilitate the communication between audience and speakers present at the venue and can extend the reach of a conference to participants following along from home. To examine whether Twitter activity can serve as a surrogate parameter for attendance at the RSNA conferences in 2019 and in 2020, and to characterize changes in topics discussed due to the virtual character of the 2020 RSNA conference.