Publications by authors named "M Kollert"
Article Synopsis
- Plasma cells (PCs) in bone marrow are key players in immune responses, involved in both diseases like multiple myeloma and conditions such as autoimmune disorders.
- Current research on human PCs is limited due to challenges in traditional culture methods; hence, a new dynamic 3D bone marrow culture system (BM-MPS) has been developed to better mimic the natural environment of PCs.
- This innovative system, supported by a collagen-hyaluronic acid hydrogel, not only preserves the native bone marrow structure but also allows for long-term survival and functionality of primary-derived non-malignant PCs, paving the way for targeted therapeutic strategies.
Aim: The challenging properties of biofilm-associated infections and the rise of multidrug-resistant bacteria are prompting the exploration of alternative treatment options. This study investigates the efficacy of different bioactive glass (BAG) formulations - alone or combined with vancomycin - to eradicate biofilm. Further, we study the influence of BAG on pH and osmotic pressure as important factors limiting bacterial growth.
View Article and Find Full Text PDFRobust mapping of relaxation parameters in ex vivo tissues is based on hydration and therefore requires control of the tissue treatment to ensure tissue integrity and consistent measurement conditions over long periods of time. One way to maintain the hydration of ex vivo tendon tissue is to immerse the samples in a buffer solution. To this end, various buffer solutions have been proposed; however, many appear to influence the tissue relaxation times, especially with prolonged exposure.
View Article and Find Full Text PDFAdipose tissue engineering aims to provide solutions to patients who require tissue reconstruction following mastectomies or other soft tissue trauma. Mesenchymal stromal cells (MSCs) robustly differentiate into the adipogenic lineage and are attractive candidates for adipose tissue engineering. This work investigates whether pore size modulates adipogenic differentiation of MSCs toward identifying optimal scaffold pore size and whether pore size modulates spatial infiltration of adipogenically differentiated cells.
View Article and Find Full Text PDFObjective: To demonstrate the functional long-term results after reconstruction of the lower lip with the tongue flap.
Methods: We describe the surgical technique and long-term results of lower lip reconstruction with the tongue flap and review five cases in which this technique was used to reconstruct defects of the lower lip, particularly the lip vermilion.
Results: Between 1993 and 2003 we performed reconstruction of the lower lip using the tongue flap in five patients.