Publications by authors named "M Koldas"
Background: The aim of this study was to determine the reference intervals of 14 clinical biochemistry tests in healthy individuals aged 18 - 65 years. The reference intervals determined by using direct and indirect methods were compared with each other and the manufacturer's RI in terms of gender.
Methods: Blood was collected from 302 reference subjects selected on the basis of admission and exclusion criteria based on the procedures set out in document C28-A3, and 14 clinical chemistry tests were performed using the analytical systems available in our laboratory.
Article Synopsis
- - The study explores sigma methodology in clinical laboratories to assess process performance and improve patient safety by identifying performance gaps through sigma metrics and quality target index (QGI) values from internal quality control data in coagulation tests.
- - Sigma levels are classified as "world-class," "good," or "unacceptable" based on a formula involving total allowable error (TEa) and coefficient of variation (CV), while QGI values help pinpoint issues in accuracy or precision, guiding necessary improvements.
- - Results indicated that both prothrombin time (PT) and activated partial thromboplastin time (APTT) tests had sigma values below 3, signaling low quality; subsequent actions for improvement were deemed necessary for the laboratory's coagulation parameters
Parental Perspectives on Early Life Screening and Genetic Testing for ASD: A Systematic Review.
J Autism Dev Disord
February 2024
Autism Spectrum Disorder (ASD) is a prevalent neurodevelopmental condition for which no prenatal or early life screening tests exist. Early life recognition of ASD is key to accessing behavioral intervention when brain plasticity is at its peak. The purpose of our study was to systematically review the literature researching parental perspectives around early life screening for autism and specifically genetic testing.
View Article and Find Full Text PDFBackground: Evaluating predictors of coronavirus disease 2019 (COVID-19) and severity among children may help clinicians manage the high rate of hospital admissions for suspected cases.
Objectives: This study aimed to evaluate the demographic, clinical and laboratory characteristics of children during the pandemic, and determine the predictors of COVID-19 and moderate-to-severe disease.
Material And Methods: This retrospective cohort study included all consecutive COVID-19 cases in patients aged <18 years who presented to the Pediatric Emergency Department at Haseki Training and Research Hospital (Istanbul, Turkey) between March 15 and May 1, 2020, and underwent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) analysis of oro-nasopharyngeal swabs (n = 1137).
Objective: The study aimed to investigate the predictive power of serum corin levels for distinguishing between hypertensive urgency (HU) and hypertensive emergency (HE) in patients with hypertensive crisis (HC) admitted to the emergency department.
Methods: A total of 120 consecutive consenting adult patients diagnosed with HC and 55 age- and sex-matched healthy controls were enrolled. Blood pressure measurements [(systolic, diastolic, and mean arterial pressure (MAP)] and the evidence of end-organ damage at the first admission were recorded.