Publications by authors named "M Kolaric"

Article Synopsis
  • NKG2D is a receptor on immune cells that helps target and eliminate cancer cells by recognizing specific ligands, leading to the development of bispecific antibodies that redirect immune cells to cancer cells with the ErbB2 (HER2) antigen.
  • Researchers created cross-reactive scFv antibodies by immunizing chickens and screening a yeast library, resulting in four new antibodies reformatted into bispecific engagers (scNKAB-ErbB2) that bind to both ErbB2-positive cancer cells and NKG2D-expressing immune cells.
  • All four tested scNKAB-ErbB2 antibodies demonstrated effectiveness in activating immune cells against cancer targets, indicating their potential for further development in cancer immunotherapy.
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